Ganciclovir-resistant cytomegalovirus encephalitis in a hematopoietic stem cell transplant recipient

被引：11
|
作者：
Arslan, Ferhat [1 ]
Tabak, Fehmi [1 ]
Avsar, Emin [2 ]
Midilli, Kenan [3 ]
Mert, Ali [1 ]
Ozaras, Resat [1 ]
Soysal, Teoman [2 ]
Ozturk, Recep [1 ]
Ferhanoglu, Burhan [2 ]
机构：
[1] Istanbul Univ, Cerrahpasa Med Fac, Dept Infect Dis, Istanbul, Turkey
[2] Istanbul Univ, Cerrahpasa Med Fac, Dept Internal Med, Sect Hematol, Istanbul, Turkey
[3] Istanbul Univ, Cerrahpasa Med Fac, Dept Clin Microbiol & Microbiol, Istanbul, Turkey
来源：
JOURNAL OF NEUROVIROLOGY | 2010年 / 16卷 / 02期
关键词：
DISEASE; AIDS; VENTRICULOENCEPHALITIS;
D O I：
10.3109/13550281003682539
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We describe a 41-year-old patient, who upon receiving a bone marrow transplant in order to treat chronic myeloid leukemia, developed cytomegalovirus (CNV) retinitis and encephalitis under the ganciclovir maintenance treatment. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid and blood showed CMV DNA with a UL97 mutation (M460V) known to confer ganciclovir resistance. Foscarnet resistance mutations were not found. Although therapy was switched to foscarnet when ganciclovir resistance was suspected, the patient was lost on posttransplant day 200.
引用
收藏
页码：174 / 178
页数：5
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