GSK-3β, a pivotal kinase in Alzheimer disease

被引：472
作者：
Llorens-Martin, Maria [1 ,2 ]
Jurado, Jeronimo [1 ,2 ]
Hernandez, Felix [1 ,2 ,3 ]
Avila, Jesus [1 ,2 ]
机构：
[1] Univ Autonoma Madrid, Consejo Super Invest Cient, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain
[2] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
[3] Univ Autonoma Madrid, Fac Biol, E-28049 Madrid, Spain
来源：
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2014年 / 7卷
关键词：
GSK-3; beta; Alzheimer disease; kinase; neurodegeneration; tau proteins; GLYCOGEN-SYNTHASE KINASE-3; CYCLIN-DEPENDENT KINASE-5; RABBIT SKELETAL-MUSCLE; HIPPOCAMPUS IN-VIVO; TAU-PROTEIN; TRANSGENIC MICE; A-BETA; SYNAPSE ELIMINATION; SIGNALING PATHWAY; PHOSPHORYLATION SITES;
D O I：
10.3389/fnmol.2014.00046
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alzheimer disease (AD) is the most common form of age-related dementia. The etiology of AD is considered to be multifactorial as only a negligible percentage of cases have a familial or genetic origin. Glycogen synthase kinase-3 (GSK-3) is regarded as a critical molecular link between the two histopathological hallmarks of the disease, namely senile plagues and neurofibrillary tangles. In this review, we summarize current data regarding the involvement of this kinase in several aspects of AD development and progression, as well as key observations highlighting GSK-3 as one of the most relevant targets for AD treatment.
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页数：11
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共 169 条
[81]   Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years [J].
Knoth, Rolf ;
Singec, Ilyas ;
Ditter, Margarethe ;
Pantazis, Georgios ;
Capetian, Philipp ;
Meyer, Ralf P. ;
Horvat, Volker ;
Volk, Benedikt ;
Kempermann, Gerd .
PLOS ONE, 2010, 5 (01)
[82]   Amyloid-beta-induced neurotoxicity is reduced by inhibition of glycogen synthast kinase-3 [J].
Koh, Seong-Ho ;
Noh, Min Young ;
Kim, Seung Hyun .
BRAIN RESEARCH, 2008, 1188 :254-262
[83]   Membrane-anchored metalloprotease MDC9 has an α-secretase activity responsible for processing the amyloid precursor protein [J].
Koike, H ;
Tomioka, S ;
Sorimachi, H ;
Saido, TC ;
Maruyama, K ;
Okuyama, A ;
Fujisawa-Sehara, A ;
Ohno, S ;
Suzuki, K ;
Ishiura, S .
BIOCHEMICAL JOURNAL, 1999, 343 :371-375
[84]   Soluble Aβ oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain [J].
Kokubo, H ;
Kayed, R ;
Glabe, CG ;
Yamaguchi, H .
BRAIN RESEARCH, 2005, 1031 (02) :222-228
[85]   Indirubins inhibit glycogen synthase kinase-3β and CDK5/P25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease -: A property common to most cycline-dependent kinase inhibitors? [J].
Leclerc, S ;
Garnier, M ;
Hoessel, R ;
Marko, D ;
Bibb, JA ;
Snyder, GL ;
Greengard, P ;
Biernat, J ;
Wu, YZ ;
Mandelkow, EM ;
Eisenbrand, G ;
Meijer, L .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (01) :251-260
[86]   Paullones are potent inhibitors of glycogen synthase kinase-3β and cyclin-dependent kinase 5/p25 [J].
Leost, M ;
Schultz, C ;
Link, A ;
Wu, YZ ;
Biernat, J ;
Mandelkow, EM ;
Bibb, JA ;
Snyder, GL ;
Greengard, P ;
Zaharevitz, DW ;
Gussio, R ;
Senderowicz, AM ;
Sausville, EA ;
Kunick, C ;
Meijer, L .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 2000, 267 (19) :5983-5994
[87]   Increased level of active GSK-3β in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration [J].
Leroy, K. ;
Yilmaz, Z. ;
Brion, J. -P. .
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2007, 33 (01) :43-55
[88]   Increase of BDNF Serum Concentration in Lithium Treated Patients with Early Alzheimer's Disease [J].
Leyhe, Thomas ;
Eschweiler, Gerhard W. ;
Stransky, Elke ;
Gasser, Thomas ;
Annas, Peter ;
Basun, Hans ;
Laske, Christoph .
JOURNAL OF ALZHEIMERS DISEASE, 2009, 16 (03) :649-656
[89]   Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3β [J].
Li, T ;
Hawkes, C ;
Qureshi, HY ;
Kar, S ;
Paudel, HK .
BIOCHEMISTRY, 2006, 45 (10) :3134-3145
[90]   Glycogen synthase kinase 3β phosphorylates Alzheimer's disease-specific Ser396 of microtubule-associated protein tau by a sequential mechanism [J].
Li, T ;
Paudel, HK .
BIOCHEMISTRY, 2006, 45 (10) :3125-3133
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