To study the jet penetration capability of shaped charge warhead of guided ammunition, a variable cone angle-shaped charge liner was designed. LS-DYNA software is used to simulate the penetration capability of shaped charge warhead with three different metal materials (copper, steel, and aluminum). Numerical simulation results show that the velocity of the shaped charge jet formed by the three kinds of materials is v(aluminum) > v(copper) > v(steel), and the residual velocity after penetration is V-steel > V-aluminum > V-copper, the time when the jet starts to break is t(copper) > t(steel) > t(aluminum), and the penetration completion time is T-copper < T-aluminum < T-steel; therefore, according to the numerical simulation results, copper was selected as the liner material, and the principle prototype is made for the experiment. 'e results of numerical simulation and experiment show that the shaped charge warhead with copper shaped charge liner has good penetration ability and after-effect damage ability to steel target after penetrating the guidance section, steering gear section, and control section.