A Universal Tumor-Specific Promoter for Cancer Gene Therapy

被引：8

作者：

Alekseenko, I. V. ^{[1
,2
]}

Pleshkan, V. V. ^{[1
,2
]}

Sass, A. V. ^{[1
]}

Filyukova, O. B. ^{[1
]}

Snezhkov, E. V. ^{[1
]}

Sverdlov, E. D. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

[2] Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia

来源：

DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2018年 / 480卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

CELL LUNG-CANCER; EXPRESSION;

D O I：

10.1134/S1607672918030092

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An artificial double tandem tumor-specific promoter based on survivin and human telomerase reverse transcriptase gene promoters was constructed. Studies in in vitro and ex vivo therapeutic systems showed that the designed promoter exhibits a high activity in tumor cells, which is comparable to the activity of the CMV constitutive promoter.

引用

页码：158 / 161

页数：4

共 11 条

[1] Activity of the Upstream Component of Tandem TERT/Survivin Promoters Depends on Features of the Downstream Component [J].

Alekseenko, Irina V. ;

Pleshkan, Victor V. ;

Kopantzev, Eugene P. ;

Stukacheva, Elena A. ;

Chernov, Igor P. ;

Vinogradova, Tatyana V. ;

Sverdlov, Eugene D. .

PLOS ONE, 2012, 7 (10)

[2] Effectiveness of HSV-tk Suicide Gene Therapy Driven by the Grp78 Stress-Inducible Promoter in Esophagogastric Junction and Gastric Adenocarcinomas [J].

Azatian, Armen ;

Yu, Hong ;

Dai, Wande ;

Schneiders, Fiona I. ;

Botelho, Natalia K. ;

Lord, Reginald V. N. .

JOURNAL OF GASTROINTESTINAL SURGERY, 2009, 13 (06) :1044-1051

[3]

Clive KS, 2010, EXPERT REV VACCINES, V9, P519, DOI [10.1586/erv.10.40, 10.1586/ERV.10.40]

[4] Hybrid Promoters Directed tBid Gene Expression to Breast Cancer Cells by Transcriptional Targeting [J].

Farokhimanesh, Samila ;

Rahbarizadeh, Fatemeh ;

Rasaee, Mohammad J. ;

Kamali, Abbas ;

Mashkani, Baratali .

BIOTECHNOLOGY PROGRESS, 2010, 26 (02) :505-511

[5]

FREEMAN SM, 1993, CANCER RES, V53, P5274

[6] Concordant expression of the telomerase-associated genes in non-small cell lung cancer [J].

Hsu, CP ;

Miaw, J ;

Hsia, JY ;

Shai, SE ;

Chen, CY .

EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, 2003, 29 (07) :594-599

[7] Clinical development of gene therapy for colorectal cancer [J].

Kerr, D .

NATURE REVIEWS CANCER, 2003, 3 (08) :615-622

[8] Delivery of Hypoxia and Glioma Dual-Specific Suicide Gene Using Dexamethasone Conjugated Polyethylenimine for Glioblastoma-Specific Gene Therapy [J].

Kirn, Hyun Ah ;

Park, Jin Hyeong ;

Yi, Na ;

Lee, Minhyung .

MOLECULAR PHARMACEUTICS, 2014, 11 (03) :938-950

[9] Bystander Killing Effect of Tymidine Kinase Gene-Transduced Adult Bone Marrow Stromal Cells With Ganciclovir on Malignant Glioma Cells [J].

Mori, Kentaro ;

Iwata, Junko ;

Miyazaki, Masahiro ;

Osada, Hideo ;

Tange, Yuichi ;

Yamamoto, Takuji ;

Aiko, Yasuhisa ;

Tamura, Masaru ;

Shiroishi, Toshihiko .

NEUROLOGIA MEDICO-CHIRURGICA, 2010, 50 (07) :545-553

[10] A chimeric fusion of the hASH1 and EZH2 promoters mediates high and specific reporter and suicide gene expression and cytotoxicity in small cell lung cancer cells [J].

Poulsen, T. T. ;

Pedersen, N. ;

Juel, H. ;

Poulsen, H. S. .

CANCER GENE THERAPY, 2008, 15 (09) :563-575

← 1 2 →