Molecular imaging and therapy of atherosclerosis with targeted nanoparticles

被引：161
作者：
Wickline, Samuel A.
Neubauer, Anne M.
Winter, Patrick M.
Caruthers, Shelton D.
Lanza, Gregory M.
机构：
[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[2] Washington Univ, Dept Biomed Engn, St Louis, MO 63110 USA
[3] Philips Med Syst, Best, Netherlands
来源：
JOURNAL OF MAGNETIC RESONANCE IMAGING | 2007年 / 25卷 / 04期
关键词：
nanotechnology; contrast agents; imaging; drug therapy; atherosclerosis;
D O I：
10.1002/jmri.20866
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Advances in bionanotechnology are poised to impact the field of cardiovascular diagnosis and therapy for decades to come. This review seeks to illustrate selected examples of newly developed diagnostic and therapeutic nanosystems that have been evaluated in experimental atherosclerosis, thrombosis, and vascular biology. We review a variety of nanotechnologies that are capable of detecting early cardiovascular pathology, as well as associated imaging approaches and conjunctive strategies for site-targeted treatment with nanoparticle delivery systems.
引用
收藏
页码：667 / 680
页数：14
相关论文
共 50 条
  • [1] Nanoparticles for Optical Molecular Imaging of Atherosclerosis
    Douma, Kim
    Prinzen, Lenneke
    Slaaf, Dick W.
    Reutelingsperger, Chris P. M.
    Biessen, Erik A. L.
    Hackeng, Tilman M.
    Post, Mark J.
    van Zandvoort, Marc A. M. J.
    SMALL, 2009, 5 (05) : 544 - 557
  • [2] Targeted Nanoparticles for Cardiovascular Molecular Imaging
    Strijkers G.J.
    Current Radiology Reports, 2013, 1 (3) : 191 - 204
  • [3] Targeted nanoparticles for imaging and therapy of endometriosis
    Slayden, Ov
    Luo, Fangzhou
    Park, Youngrong
    Moses, Abraham S.
    Demessie, Ananiya A.
    Singh, Prem
    Korzun, Tetiana
    Taratula, Olena
    Taratula, Oleh
    BIOLOGY OF REPRODUCTION, 2024, 110 (06) : 1191 - 1200
  • [4] Targeted Molecular Imaging of Cardiovascular Diseases by Iron Oxide Nanoparticles
    Vazquez-Prada, Karla X.
    Lam, Jacinta
    Kamato, Danielle
    Xu, Zhi Ping
    Little, Peter J.
    Ta, Hang T.
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2021, 41 (02) : 601 - 613
  • [5] Nanotechnology for molecular imaging and targeted therapy
    Wickline, SA
    Lanza, GM
    CIRCULATION, 2003, 107 (08) : 1092 - 1095
  • [6] Molecular imaging of angiogenesis in early-stage atherosclerosis with αvβ3-Integrin-targeted nanoparticles
    Winter, PM
    Morawski, AM
    Caruthers, SD
    Fuhrhop, RW
    Zhang, HY
    Williams, TA
    Allen, JS
    Lacy, EK
    Robertson, JD
    Lanza, GM
    Wickline, SA
    CIRCULATION, 2003, 108 (18) : 2270 - 2274
  • [7] Multifunctional magnetic nanoparticles for targeted imaging and therapy
    McCarthy, Jason R.
    Weissleder, Ralph
    ADVANCED DRUG DELIVERY REVIEWS, 2008, 60 (11) : 1241 - 1251
  • [8] Molecular Imaging of Macrophages in Atherosclerosis
    Aikawa E.
    New S.E.P.
    Miyazaki T.
    Fukuda D.
    Aikawa M.
    Current Cardiovascular Imaging Reports, 2012, 5 (1) : 45 - 52
  • [9] Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy
    Tassa, Carlos
    Shaw, Stanley Y.
    Weissleder, Ralph
    ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) : 842 - 852
  • [10] Echocardiographic Molecular Imaging of the Effect of Anticytokine Therapy for Atherosclerosis
    Shentu, Weihui
    Ozawa, Koya
    Nguyen, The Anh
    Wu, Melinda D.
    Packwood, William
    Xie, Aris
    Muller, Matthew A.
    Brown, Eran
    Hagen, Matthew W.
    Lopez, Jose A.
    Lindner, Jonathan R.
    JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 2021, 34 (04) : 433 - +
12345