Molecular imaging and therapy of atherosclerosis with targeted nanoparticles

被引：161
|
作者：
Wickline, Samuel A.
Neubauer, Anne M.
Winter, Patrick M.
Caruthers, Shelton D.
Lanza, Gregory M.
机构：
[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[2] Washington Univ, Dept Biomed Engn, St Louis, MO 63110 USA
[3] Philips Med Syst, Best, Netherlands
来源：
JOURNAL OF MAGNETIC RESONANCE IMAGING | 2007年 / 25卷 / 04期
关键词：
nanotechnology; contrast agents; imaging; drug therapy; atherosclerosis;
D O I：
10.1002/jmri.20866
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Advances in bionanotechnology are poised to impact the field of cardiovascular diagnosis and therapy for decades to come. This review seeks to illustrate selected examples of newly developed diagnostic and therapeutic nanosystems that have been evaluated in experimental atherosclerosis, thrombosis, and vascular biology. We review a variety of nanotechnologies that are capable of detecting early cardiovascular pathology, as well as associated imaging approaches and conjunctive strategies for site-targeted treatment with nanoparticle delivery systems.
引用
收藏
页码：667 / 680
页数：14
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