Innate lymphoid cells in kidney diseases

被引：12

作者：

Wang, Ruifeng ^{[1
]}

Wang, Yiping ^{[1
]}

Harris, David C. H. ^{[1
]}

Cao, Qi ^{[1
]}

机构：

[1] Univ Sydney, Westmead Inst Med Res, Ctr Transplant & Renal Res, 176 Hawkesbury Rd, Sydney, NSW, Australia

来源：

KIDNEY INTERNATIONAL | 2021年 / 99卷 / 05期

基金：

英国医学研究理事会;

关键词：

innate immunity; innate lymphoid cells; kidney disease; therapy; IMMUNE-RESPONSES; IL-33; PROMOTES; VITAMIN-D; T-CELL; TYPE-2; INFLAMMATION; PLASTICITY; HOMEOSTASIS; IL-1-BETA; INFECTION;

D O I：

10.1016/j.kint.2020.11.023

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

It is well known that innate immune cells, including dendritic cells, macrophages, and natural killer cells, contribute to pathogenesis and protection in various kidney diseases. The understanding of innate immunity has been advanced recently by the discovery of a new group of innate lymphoid cells (ILCs), including ILC1, ILC2, and ILC3. ILCs lack adaptive antigen receptors, yet can be triggered by various pathogens and rapidly provide an abundant source of immunomodulatory cytokines to exert immediate immune reactions and direct subsequent innate and adaptive immune responses. ILCs play critical roles in immunity, tissue homeostasis, and pathological inflammation. In this review, we highlight the biological function of ILC subpopulations in the normal kidney, and their important roles in acute and chronic kidney diseases, thus demonstrating the emerging importance of ILC-regulated immunity in this special organ and providing insights for future research directions and therapeutic interventions.

引用

页码：1077 / 1087

页数：11

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