The effects of phthalate ester exposure on human health: A review

被引：246

作者：

Chang, Wei-Hsiang ^{[1
]}

Herianto, Samuel ^{[1
,2
,3
,4
]}

Lee, Ching-Chang ^{[5
]}

Hung, Hsin ^{[1
]}

Chen, Hsiu-Ling ^{[1
]}

机构：

[1] Natl Cheng Kung Univ, Dept Food Safety Hyg & Risk Management, Coll Med, Tainan 70101, Taiwan

[2] Acad Sinica, Taiwan Int Grad Program TIGP, Chem Biol & Mol Biophys Program, Taipei 11529, Taiwan

[3] Acad Sinica, Inst Biol Chem, Taipei 11529, Taiwan

[4] Natl Taiwan Univ, Dept Chem, Coll Sci, Chem Biol Div, Taipei 10617, Taiwan

[5] Natl Cheng Kung Univ, Coll Med, Res Ctr Environm Trace Tox Subst, Tainan 70101, Taiwan

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2021年 / 786卷

关键词：

PAE exposure; Health effects; Diseases; Phthalate esters; PAE metabolites; TANDEM MASS-SPECTROMETRY; SEMEN QUALITY PARAMETERS; CORONARY-HEART-DISEASE; CARE PRODUCT USE; BISPHENOL-A; DI(2-ETHYLHEXYL) PHTHALATE; THYROID-FUNCTION; URINARY CONCENTRATIONS; PLASTIC FILM; METABOLITE CONCENTRATIONS;

D O I：

10.1016/j.scitotenv.2021.147371

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Phthalate esters (PAEs) are one of the most widely used plasticizers in polymer products and humans are increasingly exposed to them. The constant exposure to PAEs-contained products has raised some concerns against human health. Thus, the impacts of PAEs and their metabolites on human health require a comprehensive study for a better understanding of the associated risks. Here, we attempt to review eight main health effects of PAE exposure according to the most up-to-date studies. We found that epidemiological studies demonstrated a consistent association between PAE exposure (especially DEHP and its metabolites) and a decrease in sperm quality in males and symptom development of ADHD in children. Overall, we found insufficient evidence and lack of consistency of the association between PAE exposure and cardiovascular diseases (hypertension, atherosclerosis, and CHD), thyroid diseases, respiratory diseases, diabetes, obesity, kidney diseases, intelligence performance in children, and other reproductive system-related diseases (anogenital distance, girl precocious puberty, and endometriosis). Future studies (longitudinal and follow-up investigations) need to thoroughly perform in large-scale populations to yield more consistent and powerful results and increase the precision of the association as well as enhance the overall understanding of potential human health risks of PAEs in long-term exposure. (c) 2021 Published by Elsevier B.V.

引用

页数：16

共 183 条

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