Closed-Loop Control of Reactive Crystallization. Part I: Supersaturation-Controlled Crystallization of L-Glutamic Acid

被引：14
作者：
Alatalo, Hannu M. [1 ]
Hatakka, Henry [1 ]
Louhi-Kultanen, Marjatta [1 ]
Kohonen, Jarno [1 ]
Reinikainen, Satu-Pia [1 ]
机构：
[1] Lappeenranta Univ Technol, Lappeenranta 53851, Finland
来源：
CHEMICAL ENGINEERING & TECHNOLOGY | 2010年 / 33卷 / 05期
基金：
芬兰科学院;
关键词：
Closed-loop control; Crystallization; L-Glutamic acid; Supersaturation; ATR-FTIR SPECTROSCOPY; SITU RAMAN-SPECTROSCOPY; PHARMACEUTICAL CRYSTALLIZATION; POLYMORPHIC TRANSFORMATION; ANTISOLVENT CRYSTALLIZATION; LASER BACKSCATTERING; FEEDBACK-CONTROL; DIRECT DESIGN; ALPHA-FORM; PRECIPITATION;
D O I：
10.1002/ceat.200900550
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
The feedback control policy of the reactive crystallization process is studied. A concentration of a crystallizing compound is used to compute the feedback in the closed-loop control of semi-batch precipitation. The pH is used as a second feedback value, and the dynamic change of the set value is based on the mass of added acid. The concentration of L-glutamic acid is determined from measured MID-IR attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectra based on a multivariate model. The importance of the supersaturation level control at the nucleation moment and the effect of different supersaturation levels on the quality of the product crystals are studied by using a 50-I, crystallizer. The studied crystal properties of the product are polymorphism (reported metastable a- and stable beta-forms) and crystal size. The results show that the feedback process control system developed in this study makes it possible to control the formation of polymorphs effectively.
引用
收藏
页码：743 / 750
页数：8
相关论文
共 36 条
  • [1] ALATALO H, AICHE IN PRESS, DOI DOI 10.1002/AIC.12137
  • [2] In-line monitoring of reactive crystallization process based on ATR-FTIR and Raman spectroscopy
    Alatalo, Hannu
    Kohonen, Jarno
    Qu, Haiyan
    Hatakka, Henry
    Reinikainen, Satu-Pia
    Louhi-Kultanen, Marjatta
    Kallas, Juha
    [J]. JOURNAL OF CHEMOMETRICS, 2008, 22 (11-12) : 644 - 652
  • [3] Modeling the precipitation of L-glutamic acid via acidification of monosodium glutantate
    Borissova, A
    Jammoal, Y
    Javed, KH
    Lai, X
    Mahmud, T
    Penchev, R
    Roberts, KJ
    Wood, W
    [J]. CRYSTAL GROWTH & DESIGN, 2005, 5 (03) : 845 - 854
  • [4] Brittain H. G., 1999, POLYMORPHISM PHARM S
  • [5] Dai Y., 2007, THESIS LAPPEENRANTA
  • [6] Polymorphism in molecular crystals: Stabilization of a metastable form by conformational mimicry
    Davey, RJ
    Blagden, N
    Potts, GD
    Docherty, R
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (07) : 1767 - 1772
  • [7] DHAMELINCOURT P, 1991, J RAMAN SPECTROSC, V22, P582
  • [8] AN INVESTIGATION OF THE APPLICABILITY OF ATTENUATED TOTAL-REFLECTION INFRARED-SPECTROSCOPY FOR MEASUREMENT OF SOLUBILITY AND SUPERSATURATION OF AQUEOUS CITRIC-ACID SOLUTIONS
    DUNUWILA, DD
    CARROLL, LB
    BERGLUND, KA
    [J]. JOURNAL OF CRYSTAL GROWTH, 1994, 137 (3-4) : 561 - 568
  • [9] ATR FTIR spectroscopy for in situ measurement of supersaturation
    Dunuwila, DD
    Berglund, KA
    [J]. JOURNAL OF CRYSTAL GROWTH, 1997, 179 (1-2) : 185 - 193
  • [10] Solution-mediated transformation of α to β L-glutamic acid:: Rate enhancement due to secondary nucleation
    Ferrari, ES
    Davey, RJ
    [J]. CRYSTAL GROWTH & DESIGN, 2004, 4 (05) : 1061 - 1068
1234