Paradoxical somatodendritic decoupling supports cortical plasticity during REM sleep

被引：61

作者：

Aime, Mattia ^{[1
,2
]}

Calcini, Niccolo ^{[1
,2
]}

Borsa, Micaela ^{[1
,2
]}

Campelo, Tiago ^{[1
,2
]}

Rusterholz, Thomas ^{[1
,2
]}

Sattin, Andrea ^{[3
]}

Fellin, Tommaso ^{[3
]}

Adamantidis, Antoine ^{[1
,2
]}

机构：

[1] Univ Hosp Bern, Inselspital, Dept Neurol, Zentrum Expt Neurol, Bern, Switzerland

[2] Univ Bern, Dept Biomed Res, Bern, Switzerland

[3] Ist Italiano Tecnol, Opt Approaches Brain Funct Lab, Genoa, Italy

来源：

SCIENCE | 2022年 / 376卷 / 6594期

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

LONG-TERM POTENTIATION; EYE-MOVEMENT SLEEP; WAKE CYCLE; NEURONS; DEPRIVATION; EXPRESSION; CORTEX; CONNECTIVITY; ACTIVATION; GLUTAMATE;

D O I：

10.1126/science.abk2734

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rapid eye movement (REM) sleep is associated with the consolidation of emotional memories. Yet, the underlying neocortical circuits and synaptic mechanisms remain unclear. We found that REM sleep is associated with a somatodendritic decoupling in pyramidal neurons of the prefrontal cortex. This decoupling reflects a shift of inhibitory balance between parvalbumin neuron-mediated somatic inhibition and vasoactive intestinal peptide-mediated dendritic disinhibition, mostly driven by neurons from the central medial thalamus. REM-specific optogenetic suppression of dendritic activity led to a loss of danger-versus-safety discrimination during associative learning and a lack of synaptic plasticity, whereas optogenetic release of somatic inhibition resulted in enhanced discrimination and synaptic potentiation. Somatodendritic decoupling during REM sleep promotes opposite synaptic plasticity mechanisms that optimize emotional responses to future behavioral stressors.

引用

页码：724 / +

页数：33

共 43 条

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