Self-initiated surface grafting with poly(2-methacryloyloxyethyl phosphorylcholine) on poly(ether-ether-ketone)

被引:130
作者
Kyomoto, Masayuki [1 ,2 ,5 ]
Moro, Toru [2 ,3 ]
Takatori, Yoshio [2 ,3 ]
Kawaguchi, Hiroshi [3 ]
Nakamura, Kozo [3 ]
Ishihara, Kazuhiko [1 ,4 ]
机构
[1] Univ Tokyo, Dept Mat Engn, Sch Engn, Bunkyo Ku, Tokyo 1138656, Japan
[2] Univ Tokyo, Grad Sch Med, Div Sci Joint Reconstruct, Bunkyo Ku, Tokyo 1138655, Japan
[3] Univ Tokyo, Fac Med, Bunkyo Ku, Tokyo 1138655, Japan
[4] Univ Tokyo, Ctr NanoBio Integrat, Bunkyo Ku, Tokyo 1138656, Japan
[5] Japan Med Mat Corp, Res Dept, Yodogawa Ku, Osaka 5320003, Japan
关键词
Polyetheretherketone; Phosphorylcholine; Surface modification; Photopolymerization; Protein adsorption; Friction; POLY(ETHER ETHER KETONE); FIBER-REINFORCED PEEK; 2-METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE; PHOSPHOLIPID POLYMER; BIOCOMPATIBLE POLYMER; ARTIFICIAL JOINTS; POLYETHYLENE; MEMBRANES; ACID; WEAR;
D O I
10.1016/j.biomaterials.2009.10.055
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Poly(ether-ether-ketone) (PEEK)s are a group of polymeric biomaterials with excellent mechanical properties and chemical stability. In the present study, we demonstrate the fabrication of an antibiofouling and highly hydrophilic high-density nanometer-scaled layer on the surface of PEEK by photo-induced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) without using any photo-initiators, i.e., "self-initiated surface graft polymerization." Our results indicated that the diphenylketone moiety in the polymer backbone acted as a photo-initiator similar to benzophenone. The density and thickness of the poly(MPC) (PMPC)-grafted layer were controlled by the photo-irradiation time and monomer concentration during polymerization, respectively. Since MPC is a highly hydrophilic compound, the water wettability (contact angle <10 degrees) and lubricity (coefficient of dynamic friction <0.01) of the PMPC-grafted PEEK surface were considerably lower than those of the untreated PEEK surface (90 degrees and 0.20, respectively) due to the formation of a PMPC nanometer-scale layer. In addition, the amount (0.05 mu g/cm(2)) of BSA adsorbed on the PMPC-grafted PEEK surface was considerably lower, that is more than 90% reduction, compared to that (0.55 mu g/cm(2)) for untreated PEEK. This photo-induced polymerization process occurs only on the surface of the PEEK substrate; therefore, the desirable mechanical properties of PEEK would be maintained irrespective of the treatment used. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1017 / 1024
页数:8
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