Polyaspartic acid alleviates heavy metal toxicity in zebrafish (Danio rerio)

被引：9
作者：
Liu, Tuo [1 ]
Wang, Ruilin [1 ,2 ]
Cao, Hui [3 ]
Lin, Aijun [1 ,4 ]
机构：
[1] Beijing Univ Chem Technol, Dept Environm Sci & Engn, Beijing 100029, Peoples R China
[2] Beijing Drainage Grp Co Ltd, Beijing, Peoples R China
[3] Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing, Peoples R China
[4] Beijing Univ Chem Technol, Beijing City Environm Pollut Control & Resource R, Beijing 100029, Peoples R China
来源：
CHEMISTRY AND ECOLOGY | 2017年 / 33卷 / 07期
基金：
北京市自然科学基金;
关键词：
PASP; detoxification; heavy metal; Danio rerio; OXIDATIVE STRESS; CATALASE ACTIVITY; AQUEOUS-SOLUTIONS; CHELATING-AGENTS; COPPER TOXICITY; RAINBOW-TROUT; DNA-DAMAGE; CADMIUM; PHYTOEXTRACTION; DIETS;
D O I：
10.1080/02757540.2017.1351959
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The present study was conducted to investigate the effect of polyaspartic acid (PASP) on Pb, Cu, and Cd toxicity in zebrafish (Danio rerio). After 24 hours' toxicity test on zebrafish, LC50, survival rates of zebrafish and catalase (CAT) activity were determined. The results revealed that the 24-hour survival rates of zebrafish exposed to Pb (P<.05), Cd (P<.05), and Cu (P<.05) treatment decreased with the increasing metal concentration; and the mean LC50 of Pb, Cd, and Cu for zebrafish were 5.15mg/L, 2.82mg/L, and 0.09mg/L, respectively. However, no zebrafish death was found in the group added with PASP (P<.05), indicating that the application of PASP increased the survival rate and alleviated the toxicity of heavy metal in zebrafish. The mechanisms of detoxification induced by PASP might lie in the in vitro and in vivo mechanisms.
引用
收藏
页码：684 / 693
页数：10
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