Extracellular Matrix Microfiber Papers for Constructing Multilayered 3D Composite Tissues

被引：11

作者：

Nakatsuji, Hirotaka ^{[1
]}

Matsusaki, Michiya ^{[1
,2
,3
]}

机构：

[1] Osaka Univ, Grad Sch Engn, Joint Res Lab TOPPAN Adv Cell Regulatory Chem, 2-1 Yamadaoka, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Engn, Dept Appl Chem, 2-1 Yamadaoka, Suita, Osaka 5650871, Japan

[3] JST PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2019年 / 5卷 / 11期

关键词：

Extracellular matrix; Paper; Fiber; Blood vessel; Tissue engineering; SURFACE FUNCTIONAL-GROUPS; PROTEIN ADSORPTION; ELASTIN; COLLAGEN; SCAFFOLDS; MODEL;

D O I：

10.1021/acsbiomaterials.9b00090

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

In vitro construction of highly organized three-dimentional (3D) tissues is still a key challenge for tissue engineering. In this study, we fabricated multilayered tissues composed of extracellular matrix (ECM) layer and cell layer by stacking cell-seeded ECM papers. A paperlike scaffold was prepared by simply casting dispersion of microfibered ECM. We showed the paperlike scaffold is a superior material for constructing 3D tissue because of its high permeability and cell migration ability, and our method can control the thickness and component of ECM in multilayered 3D tissues. It can contribute to construction of normal and disease tissue models.

引用

收藏

页码：5610 / 5614

页数：9

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