A specific and direct comparison of the trifluoromethyl and pentafluoro sulfanyl groups on the selective dopamine D3 antagonist 3-(3-{[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio}propyl)-1-phenyl-3-azabicyclo[3.1.0] hexane template

被引：18

作者：

Micheli, Fabrizio ^{[1
]}

Andreotti, Daniele ^{[1
]}

Braggio, Simone ^{[1
]}

Checchia, Anna ^{[1
]}

机构：

[1] GlaxoSmithKline Med Res Ctr, Neurosci Ctr Excellence, I-37135 Verona, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 15期

关键词：

Dopamine D3; Antagonist; DMPK; Pentafluorosulfanyl; Trifluoromethyl; RECEPTOR ANTAGONISTS; POTENT; SERIES; D3;

D O I：

10.1016/j.bmcl.2010.06.018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A direct and specific comparison of a trifluoromethyl group with the corresponding pentafluorosulfanyl group is made in terms of primary affinity and pharmacokinetic properties. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4566 / 4568

页数：3

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