[3H]-(R)-NPTS, a radioligand for the type 1 glycine transporter

被引：31

作者：

Lowe, JA ^{[1
]}

Drozda, SE ^{[1
]}

Fisher, K ^{[1
]}

Strick, C ^{[1
]}

Lebel, L ^{[1
]}

Schmidt, C ^{[1
]}

Hiller, D ^{[1
]}

Zandi, KS ^{[1
]}

机构：

[1] Pfizer Inc, Div Cent Res, Groton, CT 06340 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(03)00126-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of NPTS, 6, a potent inhibitor of the type I glycine transporter (GlyT1) is described, as well as preparation of 6 in optically active and tritiated form for use as a radioligand for affinity displacement assay of GlyT1. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：1291 / 1292

页数：2

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