Anti-Inflammatory and antiviral effects of water-soluble crude extract from Phragmites australis in vitro

被引：4

作者：

Zhu, Liqian ^{[1
,2
]}

Zhang, Dong ^{[1
,2
]}

Yuan, Chen ^{[1
,2
]}

Ding, Xiuyan ^{[1
,2
,3
]}

Shang, Yu ^{[4
]}

Jiang, Yuting ^{[4
]}

Zhu, Guoqiang ^{[1
,2
]}

机构：

[1] Yangzhou Univ, Coll Vet Med, Yangzhou, Jiangsu, Peoples R China

[2] Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Jiangsu, Peoples R China

[3] Yangzhou Univ, Test Ctr, Yangzhou, Jiangsu, Peoples R China

[4] Shanghai Univ, Inst Environm Pollut & Hlth, Sch Environm & Chem, Engn, Shanghai, Peoples R China

来源：

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2017年 / 30卷 / 04期

基金：

美国国家科学基金会;

关键词：

P; australis; ROS; NO; inflammation; BoHV-1; REACTIVE OXYGEN; NITRIC-OXIDE; CYTOKINE STORM; VIRUS; EXPRESSION;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Phragmitesaustralis (P australis), a world wide distributed wetland grass, is traditionally used as food making helper and spice in China. The pharmacological effect of this plant is poorly understood. Here, we demonstrated that lipopolysaccharide (LPS)-induced production of inflammatory mediators nitric oxide (NO) and reactive oxygen species (ROS), and the pro-inflammatory cytokines tumor necrosis factor-a (TNF-a) and interleukin-1 beta (IL-1 beta) in RAW264.7 macrophage were significantly inhibited by the crude extract. The inflammation pertinent signaling extra cellular signal-regulated kinase 1/2 (Erkl/2), P38MAPK, C-Jun and NF-kappaB (NF-kappa B) activated by LPS could be dramatically inhibited by this extract. It also remarkably inhibited bovine herpes virus type 1 (BoHV-1) replication in MDBK cells. Taken together, here, for the first time we provided P australisa a novel natural herb as a potential candidate for the generation of antiviral and anti-inflammatory agent.

引用

页码：1357 / 1362

页数：6

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