Cetacean Morbillivirus: Current Knowledge and Future Directions

被引：190

作者：

Van Bressem, Marie-Francoise ^{[1
]}

Duignan, Padraig J. ^{[2
]}

Banyard, Ashley ^{[3
]}

Barbieri, Michelle ^{[4
]}

Colegrove, Kathleen M. ^{[5
]}

De Guise, Sylvain ^{[6
,7
]}

Di Guardo, Giovanni ^{[8
]}

Dobson, Andrew ^{[9
]}

Domingo, Mariano ^{[10
]}

Fauquier, Deborah ^{[11
]}

Fernandez, Antonio ^{[12
]}

Goldstein, Tracey ^{[13
]}

Grenfell, Bryan ^{[9
,14
]}

Groch, Katia R. ^{[15
,16
]}

Gulland, Frances ^{[4
,17
]}

Jensen, Brenda A. ^{[18
]}

Jepson, Paul D. ^{[19
]}

Hall, Ailsa ^{[20
]}

Kuiken, Thijs ^{[21
]}

Mazzariol, Sandro ^{[22
]}

Morris, Sinead E. ^{[9
]}

Nielsen, Ole ^{[23
]}

Raga, Juan A. ^{[24
]}

Rowles, Teresa K. ^{[11
]}

Saliki, Jeremy ^{[25
]}

Sierra, Eva ^{[12
]}

Stephens, Nahiid ^{[26
]}

Stone, Brett ^{[27
]}

Tomo, Ikuko ^{[28
]}

Wang, Jianning ^{[29
]}

Waltzek, Thomas ^{[30
]}

Wellehan, James F. X. ^{[31
]}

机构：

[1] Peruvian Ctr Cetacean Res CEPEC, Cetacean Conservat Med Grp CMED, Lima 20, Peru

[2] Univ Calgary, Dept Ecosyst & Publ Hlth, Calgary, AB T2N 4Z6, Canada

[3] APHA, Wildlife Zoonoses & Vector Borne Dis Res Grp, Weybridge KT15 3NB, Surrey, England

[4] Marine Mammal Ctr, Sausalito, CA 94965 USA

[5] Univ Illinois, Coll Vet Med, Zool Pathol Program, Maywood, IL 60153 USA

[6] Univ Connecticut, Dept Pathobiol & Vet Sci, Storrs, CT 06269 USA

[7] Univ Connecticut, Connecticut Sea Grant Coll Program, Storrs, CT 06269 USA

[8] Univ Teramo, Fac Vet Med, I-64100 Teramo, Italy

[9] Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA

[10] Autonomous Univ Barcelona, Ctr Recerca Sanitat Anim CReSA, E-08193 Barcelona, Spain

[11] Natl Marine Fisheries Serv, Marine Mammal Hlth & Stranding Response Program, Silver Spring, MD 20910 USA

[12] Univ Las Palmas Gran Canaria, Sch Vet, Inst Anim Hlth, Dept Vet Pathol, Las Palmas Gran Canaria 35413, Spain

[13] Univ Calif Davis, Sch Vet Med, Hlth Inst 1, Davis, CA 95616 USA

[14] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA

[15] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, BR-05508207 Sao Paulo, Brazil

[16] Humpback Whale Inst, BR-45900000 Caravelas, Bahia, Brazil

[17] Marine Mammal Commiss, Bethesda, MD 20814 USA

[18] Hawaii Pacific Univ, Dept Nat Sci, Kaneohe, HI 96744 USA

[19] Zool Soc London, Inst Zool, London NW1 4RY, England

[20] Univ St Andrews, Scottish Oceans Inst, Sea Mammal Res Unit, St Andrews KY16 8LB, Fife, Scotland

[21] Erasmus MC, Dept Virosci, NL-3015 CN Rotterdam, Netherlands

[22] Univ Padua, Dept Comparat Biomed & Food Sci, I-35020 Padua, Italy

[23] Cent & Arctic Reg, Dept Fisheries & Oceans Canada, Winnipeg, MB R3T 2N6, Canada

[24] Univ Valencia, Cavanilles Inst Biodivers & Evolutionary Biol, Marine Zool Unit, Valencia 22085, Spain

[25] Univ Georgia, Athens Vet Diagnost Lab, Coll Vet Med, Athens, GA 30602 USA

[26] Murdoch Univ, Sch Vet & Life Sci, Perth, WA 6150, Australia

[27] QML Vetnost, Murarrie, Qld 4172, Australia

[28] S Australian Museum, Adelaide, SA 5000, Australia

[29] CSIRO, East Geelong, Vic 3220, Australia

[30] Univ Florida, Dept Infect Dis & Pathol, Coll Vet Med, Gainesville, FL 32611 USA

[31] Univ Florida, Dept Small Anim Clin Sci, Coll Vet Med, Gainesville, FL 32611 USA

来源：

VIRUSES-BASEL | 2014年 / 6卷 / 12期

基金：

美国国家卫生研究院;

关键词：

cetacean morbillivirus; epidemics; mass stranding; SLAM; phylogeny; pathogenesis; diagnosis; endemic infections; BOTTLE-NOSED DOLPHINS; CANINE-DISTEMPER-VIRUS; PORPOISES PHOCOENA-PHOCOENA; POLYMERASE-CHAIN-REACTION; MEASLES-VIRUS; STRIPED DOLPHINS; STENELLA-COERULEOALBA; TURSIOPS-TRUNCATUS; EPITHELIAL RECEPTOR; POSTMORTEM FINDINGS;

D O I：

10.3390/v6125145

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We review the molecular and epidemiological characteristics of cetacean morbillivirus (CeMV) and the diagnosis and pathogenesis of associated disease, with six different strains detected in cetaceans worldwide. CeMV has caused epidemics with high mortality in odontocetes in Europe, the USA and Australia. It represents a distinct species within the Morbillivirus genus. Although most CeMV strains are phylogenetically closely related, recent data indicate that morbilliviruses recovered from Indo-Pacific bottlenose dolphins (Tursiops aduncus), from Western Australia, and a Guiana dolphin (Sotalia guianensis), from Brazil, are divergent. The signaling lymphocyte activation molecule (SLAM) cell receptor for CeMV has been characterized in cetaceans. It shares higher amino acid identity with the ruminant SLAM than with the receptors of carnivores or humans, reflecting the evolutionary history of these mammalian taxa. In Delphinidae, three amino acid substitutions may result in a higher affinity for the virus. Infection is diagnosed by histology, immunohistochemistry, virus isolation, RT-PCR, and serology. Classical CeMV-associated lesions include bronchointerstitial pneumonia, encephalitis, syncytia, and lymphoid depletion associated with immunosuppression. Cetaceans that survive the acute disease may develop fatal secondary infections and chronic encephalitis. Endemically infected, gregarious odontocetes probably serve as reservoirs and vectors. Transmission likely occurs through the inhalation of aerosolized virus but mother to fetus transmission was also reported.

引用

页码：5145 / 5181

页数：37

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