The present status of cell tracking methods in animal models using magnetic resonance imaging technology

被引:0
作者
Kim, Daehong
Hong, Kwan Soo
Song, Jihwan [1 ]
机构
[1] Pochon CHA Univ, Coll Med, CHA Stem Cell Inst, Seoul 135081, South Korea
[2] Natl Canc Ctr, Radiat Med Branch, Ilsan 410769, South Korea
[3] Korea Basic Sci Inst, MRI Team, Ochang 363883, South Korea
关键词
cell tracking; magnetic resonance imaging; stem cell therapy;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
With the advance of stem cell transplantation research, in vivo cell tracking techniques have become increasingly important in recent years. Magnetic resonance imaging (MRI) may provide a unique tool for noninvasive tracking of transplanted cells. Since the initial findings on the stem cell migration by MRI several years ago, there have been numerous studies using various animal models, notably in heart or brain disease models. In order to develop more reliable and clinically applicable methodologies, multiple aspects should be taken into consideration. In this review, we will summarize the current status and future perspectives of in vivo cell tracking technologies using MRI. In particular, use of different MR contrast agents and their detection methods using MRI will be described in much detail. In addition, various cell labeling methods to increase the sensitivity of signals will be extensively discussed. We will also review several key experiments, in which MRI techniques were utilized to detect the presence and/or migration of transplanted stem cells in various animal models. Finally, we will discuss the current problems and future directions of cell tracking methods using MRI.
引用
收藏
页码:132 / 137
页数:6
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