Conjugate and polysaccharide pneumococcal vaccines do not improve initial response of the polysaccharide vaccine in HIV-infected adults

被引：35

作者：

Penaranda, Maria ^{[1
]}

Payeras, Antoni ^{[2
]}

Cambra, Ana ^{[3
]}

Mila, Joan ^{[3
]}

Riera, Melcior ^{[1
]}

机构：

[1] Son Dureta Univ Hosp, Dept Internal Med, Div Infect Dis, Palma de Mallorca, Spain

[2] Son Llatzer Hosp, Dept Internal Med, Palma de Mallorca, Spain

[3] Son Dureta Univ Hosp, Dept Immunol, Palma de Mallorca, Spain

来源：

AIDS | 2010年 / 24卷 / 08期

关键词：

ANTIBODY-RESPONSE; EFFICACY; CHILDREN;

D O I：

10.1097/QAD.0b013e3283389de5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This is a randomized trial to compare the immunoglobulin G response and the antibody avidity after two pneumococcal vaccinations, conjugated pneumococcal vaccine (CPV) and polysaccharide pneumococcal vaccine (PPV) 4weeks after vs. PPV alone in 202 HIV-infected adults. There were no differences in the two strategies, either in the percentage of immunoglobulin G two-fold increase for the CPV included serotypes or immunoglobulin G two-fold increase, reaching the level of 1mg/ml except for serotype 23F (26% responded after conjugated pneumococcal vaccine + PPV vs. 14% after PPV). No avidity increases were seen in any strategy.

引用

页码：1226 / 1228

页数：3

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