Complex Investigation of the Effects of Lambertianic Acid Amide in Female Mice under Conditions of Social Discomfort

被引：2

作者：

Avgustinovich, D. F. ^{[1
,2
]}

Fomina, M. K. ^{[3
]}

Sorokina, I. V. ^{[3
]}

Tolstikova, T. G. ^{[3
]}

机构：

[1] Russian Acad Sci, Siberian Div, Inst Cytol & Genet, Moscow 117901, Russia

[2] Russian Acad Sci, Siberian Div, Res Inst Physiol & Fundamental Med, Novosibirsk, Russia

[3] Russian Acad Sci, Siberian Div, NN Vorozhtsov Novosibirsk Inst Organ Chem, Moscow 117901, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 157卷 / 05期

关键词：

female mice; social discomfort; lambertianic acid derivatives;

D O I：

10.1007/s10517-014-2621-y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of chronic administration of a new substance lambertianic acid amide and previously synthesized methyl ester of this acid were compared in female mice living under conditions of social discomfort. For modeling social discomfort, female mouse was housed for 30 days in a cage with aggressive male mouse kept behind a transparent perforated partition and observed its confrontations with another male mouse daily placed to the cage. The new agent more effectively than lambertianic acid methyl ester improved communicativeness and motor activity of animals, reduced hypertrophy of the adrenal glands, and enhanced catalase activity in the blood. These changes suggest that lambertianic acid amide produces a pronounced stress-protective effect under conditions of social discomfort.

引用

页码：583 / 587

页数：5

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