GABAA receptor γ subunits in the prefrontal cortex of patients with schizophrenia and bipolar disorder

被引：14

作者：

Ishikawa, M ^{[1
]}

Mizukami, K ^{[1
]}

Iwakiri, M ^{[1
]}

Hidaka, S ^{[1
]}

Asada, T ^{[1
]}

机构：

[1] Univ Tsukuba, Inst Clin Med, Dept Psychiat, Tsukuba, Ibaraki 3058575, Japan

来源：

NEUROREPORT | 2004年 / 15卷 / 11期

关键词：

bipolar disorder; GABA(A) receptor; gamma subunit; prefrontal cortex; schizophrenia;

D O I：

10.1097/01.wnr.0000135695.66366.08

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Immunohistochemical and immunoblot techniques were employed in order to examine alterations of the GABA(A) receptor gamma subunits in the prefrontal cortex from postmortem subjects with schizophrenia and bipolar disorder. Immunohistochemically, gamma1/3 immunolabeling in the neuronal soma in the prefrontal cortex from subjects with bipolar disorder was more intense than that of the controls and the subjects with schizophrenia. The intensity Of gamma1/3 immunolabeling of the schizophrenic subjects was comparable with that of the controls. Immunoblot analysis demonstrated a significant increase in the gamma1 subunit in the bipolar subjects, whereas no remarkable difference was detected in the schizophrenic subjects. The present study suggests that the GABA(A) receptor gamma subunit is differentially involved in schizophrenia and bipolar disorder, and that the gamma subunit is up-regulated in the prefrontal cortex of subjects with bipolar disorder.

引用

页码：1809 / 1812

页数：4

共 21 条

[1] GABA(A) RECEPTOR SUBUNIT GENE-EXPRESSION IN HUMAN PREFRONTAL CORTEX - COMPARISON OF SCHIZOPHRENICS AND CONTROLS [J].

AKBARIAN, S ;

HUNTSMAN, MM ;

KIM, JJ ;

TAFAZZOLI, A ;

POTKIN, SG ;

BUNNEY, WE ;

JONES, EG .

CEREBRAL CORTEX, 1995, 5 (06) :550-560

[2] Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics [J].

Beasley, CL ;

Reynolds, GP .

SCHIZOPHRENIA RESEARCH, 1997, 24 (03) :349-355

[3] Up-regulation of GABA(A) receptor binding on neurons of the prefrontal cortex in schizophrenic subjects [J].

Benes, FM ;

Vincent, SL ;

Marie, A ;

Khan, Y .

NEUROSCIENCE, 1996, 75 (04) :1021-1031

[4] Glutamate decarboxylase65-immunoreactive terminals in cingulate and prefrontal cortices of schizophrenic and bipolar brain [J].

Benes, FM ;

Todtenkopf, MS ;

Logiotatos, P ;

Williams, M .

JOURNAL OF CHEMICAL NEUROANATOMY, 2000, 20 (3-4) :259-269

[5] GABA(A) receptor subtypes differentiated by their gamma-subunit variants: Prevalence, pharmacology and subunit architecture [J].

Benke, D ;

Honer, M ;

Michel, C ;

Mohler, H .

NEUROPHARMACOLOGY, 1996, 35 (9-10) :1413-1423

[6] BRAIN GABA A BENZODIAZEPINE BINDING-SITES AND GLUTAMIC-ACID DECARBOXYLASE ACTIVITY IN DEPRESSED SUICIDE VICTIMS [J].

CHEETHAM, SC ;

CROMPTON, MR ;

KATONA, CLE ;

PARKER, SJ ;

HORTON, RW .

BRAIN RESEARCH, 1988, 460 (01) :114-123

[7] EVIDENCE FOR COMMON ALTERATIONS IN CEREBRAL GLUCOSE-METABOLISM IN MAJOR AFFECTIVE-DISORDERS AND SCHIZOPHRENIA [J].

COHEN, RM ;

SEMPLE, WE ;

GROSS, M ;

NORDAHL, TE ;

KING, AC ;

PICKAR, D ;

POST, RM .

NEUROPSYCHOPHARMACOLOGY, 1989, 2 (04) :241-254

[8] Changes in serotonin2A and GABAA receptors in schizophrenia:: Studies on the human dorsolateral prefrontal cortex [J].

Dean, B ;

Hussain, T ;

Hayes, W ;

Scarr, E ;

Kitsoulis, S ;

Hill, C ;

Opeskin, K ;

Copolov, DL .

JOURNAL OF NEUROCHEMISTRY, 1999, 72 (04) :1593-1599

[9] A change in the density of [3H]flumazenil, but not [3H]muscimol binding, in Brodmann's Area 9 from subjects with bipolar disorder [J].

Dean, B ;

Pavey, G ;

McLeod, M ;

Opeskin, K ;

Keks, N ;

Copolov, D .

JOURNAL OF AFFECTIVE DISORDERS, 2001, 66 (2-3) :147-158

[10] The association between antisaccade task and working memory task performance in schizophrenia and bipolar disorder [J].

Gooding, DC ;

Tallent, KA .

JOURNAL OF NERVOUS AND MENTAL DISEASE, 2001, 189 (01) :8-16

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