Analysis of thromboembolic events in head and neck cancer patients who underwent concurrent chemoradiotherapy with cisplatin

被引：4

作者：

Cho, Hundo ^{[1
]}

Choi, Jin-Hyuk ^{[1
]}

Kang, Seok Yun ^{[1
]}

Lee, Hyun Woo ^{[1
]}

Choi, Yong Won ^{[1
]}

Kim, Tae-Hwan ^{[1
]}

Ahn, Mi Sun ^{[1
]}

Kim, Chul-Ho ^{[2
]}

Shin, Yoo Seob ^{[2
]}

Jang, Jeon Yeob ^{[2
]}

Oh, Young-Taek ^{[3
]}

Heo, Jaesung ^{[3
]}

Sheen, Seung Soo ^{[4
]}

机构：

[1] Ajou Univ, Sch Med, Dept Hematol Oncol, 164 World Cup Ro, Suwon 16499, South Korea

[2] Ajou Univ, Sch Med, Dept Otolaryngol, Suwon, South Korea

[3] Ajou Univ, Sch Med, Dept Radiat Oncol, Suwon, South Korea

[4] Ajou Univ, Sch Med, Dept Pulm & Crit Care Med, Suwon, South Korea

来源：

KOREAN JOURNAL OF INTERNAL MEDICINE | 2022年 / 37卷 / 03期

关键词：

Head and neck neoplasms; Cisplatin; Chemoradiotherapy; Khorana score; VENOUS THROMBOEMBOLISM; RISK-FACTORS; CHEMOTHERAPY; THROMBOSIS;

D O I：

10.3904/kjim.2021.309

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background/Aims: The study investigated the incidence of thromboembolic events (TEE) in head and neck (H&N) cancer patients who received concurrent chemoradiotherapy (CCRT) with cisplatin, and analyzed the factors affecting TEE occur-rence Methods: Two hundred and fifty-seven patients who started CCRT with cisplatin for H&N cancer from January 2005 to De-cember 2019 were analyzed. Results: TEE occurred in five patients, an incidence rate of 1.9%. The 2-, 4-, and 6-month cumulative incidences of TEE were 0.8%, 1.6%, and 1.9%, respectively. Khorana score was the only factor associated with TEE occurrence (p = 0.010). Conclusions: The incidence of TEE in H&N cancer patients who underwent CCRT with cisplatin was relatively low when compared to other types of cancer. However, patients with a high Khorana score require more careful surveillance for possi-ble TEE occurrence.

引用

页码：653 / 659

页数：7

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