Analysis of thromboembolic events in head and neck cancer patients who underwent concurrent chemoradiotherapy with cisplatin

被引:4
作者
Cho, Hundo [1 ]
Choi, Jin-Hyuk [1 ]
Kang, Seok Yun [1 ]
Lee, Hyun Woo [1 ]
Choi, Yong Won [1 ]
Kim, Tae-Hwan [1 ]
Ahn, Mi Sun [1 ]
Kim, Chul-Ho [2 ]
Shin, Yoo Seob [2 ]
Jang, Jeon Yeob [2 ]
Oh, Young-Taek [3 ]
Heo, Jaesung [3 ]
Sheen, Seung Soo [4 ]
机构
[1] Ajou Univ, Sch Med, Dept Hematol Oncol, 164 World Cup Ro, Suwon 16499, South Korea
[2] Ajou Univ, Sch Med, Dept Otolaryngol, Suwon, South Korea
[3] Ajou Univ, Sch Med, Dept Radiat Oncol, Suwon, South Korea
[4] Ajou Univ, Sch Med, Dept Pulm & Crit Care Med, Suwon, South Korea
关键词
Head and neck neoplasms; Cisplatin; Chemoradiotherapy; Khorana score; VENOUS THROMBOEMBOLISM; RISK-FACTORS; CHEMOTHERAPY; THROMBOSIS;
D O I
10.3904/kjim.2021.309
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background/Aims: The study investigated the incidence of thromboembolic events (TEE) in head and neck (H&N) cancer patients who received concurrent chemoradiotherapy (CCRT) with cisplatin, and analyzed the factors affecting TEE occur-rence Methods: Two hundred and fifty-seven patients who started CCRT with cisplatin for H&N cancer from January 2005 to De-cember 2019 were analyzed. Results: TEE occurred in five patients, an incidence rate of 1.9%. The 2-, 4-, and 6-month cumulative incidences of TEE were 0.8%, 1.6%, and 1.9%, respectively. Khorana score was the only factor associated with TEE occurrence (p = 0.010). Conclusions: The incidence of TEE in H&N cancer patients who underwent CCRT with cisplatin was relatively low when compared to other types of cancer. However, patients with a high Khorana score require more careful surveillance for possi-ble TEE occurrence.
引用
收藏
页码:653 / 659
页数:7
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