Researching Genetic Versus Nongenetic Determinants of Disease: A Comparison and Proposed Unification

被引：64
作者：
Ioannidis, John P. A. [1 ,2 ,3 ]
Loy, En Yun [4 ]
Poulton, Richie [5 ]
Chia, Kee Seng [4 ,6 ,7 ]
机构：
[1] Univ Ioannina, Sch Med, Clin & Mol Epidemiol Unit, Dept Hyg & Epidemiol, GR-45110 Ioannina, Greece
[2] Tufts Univ, Sch Med, Dept Med, Ctr Genet Epidemiol & Modeling,Tufts Med Ctr, Boston, MA 02111 USA
[3] Fdn Res & Technol Hellas, Biomed Res Inst, Ioannina, Greece
[4] Natl Univ Singapore, Ctr Mol Epidemiol, Singapore 117548, Singapore
[5] Univ Otago, Dunedin Sch Med, Dunedin, New Zealand
[6] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Epidemiol & Publ Hlth, Singapore 117595, Singapore
[7] Karolinska Inst, Dep Med Epidemiol & Biostat, S-10401 Stockholm, Sweden
来源：
SCIENCE TRANSLATIONAL MEDICINE | 2009年 / 1卷 / 07期
关键词：
GENOME-WIDE ASSOCIATION; CANCER; EPIDEMIOLOGY; RISK; VEGETABLES; OBESITY; FRUITS;
D O I：
10.1126/scitranslmed.3000247
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Research standards deviate in genetic versus nongenetic epidemiology. Besides some immutable differences, such as the correlation pattern between variables, these divergent research standards can converge considerably. Current research designs that dissociate genetic and nongenetic measurements are reaching their limits. Studies are needed that massively measure genotypes, nongenetic exposures, and outcomes concurrently.
引用
收藏
页数：6
相关论文
共 34 条
  • [1] Annual deaths attributable to obesity in the United States
    Allison, DB
    Fontaine, KR
    Manson, JE
    Stevens, J
    VanItallie, TB
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (16): : 1530 - 1538
  • [2] Response rates to mail surveys published in medical journals
    Asch, DA
    Jedrziewski, MK
    Christakis, NA
    [J]. JOURNAL OF CLINICAL EPIDEMIOLOGY, 1997, 50 (10) : 1129 - 1136
  • [3] Network medicine -: From obesity to the "Diseasome''
    Barabasi, Albert-Laszlo
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (04) : 404 - 407
  • [4] PHENOMICS: THE SYSTEMATIC STUDY OF PHENOTYPES ON A GENOME-WIDE SCALE
    Bilder, R. M.
    Sabb, F. W.
    Cannon, T. D.
    London, E. D.
    Jentsch, J. D.
    Parker, D. Stott
    Poldrack, R. A.
    Evans, C.
    Freimer, N. B.
    [J]. NEUROSCIENCE, 2009, 164 (01) : 30 - 42
  • [5] Associations between dietary methods and biomarkers, and between fruits and vegetables and risk of ischaemic heart disease, in the EPIC Norfolk Cohort Study
    Bingham, Sheila
    Luben, Robert
    Welch, Ailsa
    Low, Yen Ling
    Khaw, Kay Tee
    Wareham, Nick
    Day, Nick
    [J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2008, 37 (05) : 978 - 987
  • [6] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    Burton, Paul R.
    Clayton, David G.
    Cardon, Lon R.
    Craddock, Nick
    Deloukas, Panos
    Duncanson, Audrey
    Kwiatkowski, Dominic P.
    McCarthy, Mark I.
    Ouwehand, Willem H.
    Samani, Nilesh J.
    Todd, John A.
    Donnelly, Peter
    Barrett, Jeffrey C.
    Davison, Dan
    Easton, Doug
    Evans, David
    Leung, Hin-Tak
    Marchini, Jonathan L.
    Morris, Andrew P.
    Spencer, Chris C. A.
    Tobin, Martin D.
    Attwood, Antony P.
    Boorman, James P.
    Cant, Barbara
    Everson, Ursula
    Hussey, Judith M.
    Jolley, Jennifer D.
    Knight, Alexandra S.
    Koch, Kerstin
    Meech, Elizabeth
    Nutland, Sarah
    Prowse, Christopher V.
    Stevens, Helen E.
    Taylor, Niall C.
    Walters, Graham R.
    Walker, Neil M.
    Watkins, Nicholas A.
    Winzer, Thilo
    Jones, Richard W.
    McArdle, Wendy L.
    Ring, Susan M.
    Strachan, David P.
    Pembrey, Marcus
    Breen, Gerome
    St Clair, David
    Caesar, Sian
    Gordon-Smith, Katherine
    Jones, Lisa
    Fraser, Christine
    Green, Elain K.
    [J]. NATURE, 2007, 447 (7145) : 661 - 678
  • [7] DANESH S, 2007, EPIDEMIOLOGY, V22, P839
  • [8] New times, new needs; e-epidemiology
    Ekman, Alexandra
    Litton, Jan-Eric
    [J]. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2007, 22 (05) : 285 - 292
  • [9] Molecular origins of cancer: Epigenetics in cancer
    Esteller, Manel
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (11) : 1148 - 1159
  • [10] Excess deaths associated with underweight, overweight, and obesity
    Flegal, KM
    Graubard, BI
    Williamson, DF
    Gail, MH
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 293 (15): : 1861 - 1867
1234