Stem Cells and Pregnancy Disorders: From Pathological Mechanisms to Therapeutic Horizons

被引：3
作者：
James, J. L. [1 ,2 ]
机构：
[1] Univ Auckland, Dept Obstet & Gynaecol, 85 Pk Rd, Auckland 1, New Zealand
[2] Univ Auckland, Fac Med & Hlth Sci, Dept Obstet & Gynaecol, 85 Pk Rd, Auckland 1, New Zealand
来源：
SEMINARS IN REPRODUCTIVE MEDICINE | 2016年 / 34卷 / 01期
关键词：
placenta; implantation; mesenchymal stem cells; trophoblast stem cells; preeclampsia; fetal growth restriction; recurrent miscarriage; INTRAUTERINE GROWTH RESTRICTION; MESENCHYMAL STROMAL CELLS; EARLY TROPHOBLAST DIFFERENTIATION; ENDOTHELIAL PROGENITOR CELLS; EMBRYO IMPLANTATION FAILURE; HUMAN TERM PLACENTA; REGULATORY T-CELLS; 1ST TRIMESTER; IN-VITRO; CHORIONIC VILLI;
D O I：
10.1055/s-0035-1570030
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Blastocyst implantation, placental development, and fetal growth are all dependent on the interactions between the developing placenta and the decidualized endometrium. Adult stem cell populations resident in both the placenta and endometrium play key roles in directing cell fate and tissue organization throughout pregnancy. As we begin to understand how these stem cell populations contribute to successful pregnancies, we can begin to ask what roles they play in the pathogenesis of pregnancy disorders from implantation failure andmiscarriage through fetal growth restriction and preeclampsia. Furthermore, as our understanding of the therapeutic applications of stem cells in other organs rapidly expands, can we make stem cell therapies a clinical reality in obstetric medicine? This review aims to summarize our current understanding of the role reproductive stem cells play in pregnancy success, and how they may help us better understand the underlying pathogenesis of pregnancy disorders to offer novel therapeutic solutions in the future.
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收藏
页码：17 / 26
页数：10
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