Photocatalyst-free decarboxylative aminoalkylation of imidazo[1,2-a]pyridines with N-aryl glycines enabled by visible light

被引：41

作者：

Ji, Jiu-Jian ^{[1
]}

Zhu, Zhi-Qiang ^{[1
,2
]}

Xiao, Li-Jin ^{[1
]}

Guo, Dong ^{[1
]}

Zhu, Xiao ^{[1
]}

Tang, Juan ^{[3
]}

Wu, Jun ^{[1
]}

Xie, Zong-Bo ^{[1
]}

Le, Zhang-Gao ^{[1
,2
]}

机构：

[1] East China Univ Technol, Sch Chem Biol & Mat Sci, Nanchang 330013, Jiangxi, Peoples R China

[2] East China Univ Technol, State Key Lab Nucl Resources & Environm, Nanchang 330013, Jiangxi, Peoples R China

[3] Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Dept Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2019年 / 6卷 / 21期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

DEHYDROGENATIVE-COUPLING REACTION; ALPHA-AMINO-ACIDS; ONE-POT SYNTHESIS; PHOTOREDOX CATALYSIS; MOLECULAR-OXYGEN; IN-VITRO; DERIVATIVES; INHIBITORS; IMIDAZOHETEROCYCLES; FUNCTIONALIZATION;

D O I：

10.1039/c9qo00935c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel, green and efficient visible-light-promoted decarboxylative aminoalkylation reaction of imidazo[1,2-a]pyridines with N-aryl glycines has been described. A diverse range of imidazo[1,2-a]pyridines undergoes the reaction well with N-aryl glycines to afford the desired corresponding products in good to high yields. This photocatalyst-free decarboxylative protocol not only manifests high regio-selectivity to biologically important imidazo[1,2-a]pyridines, but also avoids the use of expensive photosensitizers and extra additives, which makes this decarboxylative coupling more practical and sustainable.

引用

页码：3693 / 3697

页数：5

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