Particulate matter promotes hyperpigmentation via AhR/MAPK signaling activation and by increasing a-MSH paracrine levels in keratinocytes

被引:30
作者
Shi, Yaqian [1 ,2 ]
Zeng, Zhuotong [1 ,2 ]
Liu, Jiani [1 ,2 ]
Pi, Zixin [1 ,2 ]
Zou, Puyu [1 ,2 ]
Deng, Qiancheng [3 ]
Ma, Xinyu [1 ,2 ]
Qiao, Fan [1 ,2 ]
Xiong, Weiping [4 ,5 ]
Zhou, Chengyun [4 ,5 ]
Zeng, Qinghai [6 ]
Xiao, Rong [1 ,2 ]
机构
[1] Cent South Univ, Xiangya Hosp 2, Dept Dermatol, 139 Renmin Middle Rd, Changsha 410011, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Hosp 2, Hunan Key Lab Med Epigenet, Changsha 410011, Hunan, Peoples R China
[3] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Dermatol, Hangzhou 310003, Zhejiang, Peoples R China
[4] Hunan Univ, Coll Environm Sci & Engn, Changsha 410082, Hunan, Peoples R China
[5] Hunan Univ, Minist Educ, Key Lab Environm Biol & Pollut Control, Changsha 410082, Hunan, Peoples R China
[6] Cent South Univ, Xiangya Hosp 3, Dept Dermatol, Changsha 410000, Hunan, Peoples R China
基金
中国国家自然科学基金;
关键词
Particulate matter; Aryl hydrocarbon receptor; Melanogenesis; a-MSH; ARYL-HYDROCARBON RECEPTOR; AIR-POLLUTION; SKIN DISEASES; AHR; REGULATOR; EXPOSURE; STRATEGIES;
D O I
10.1016/j.envpol.2021.116850
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Particulate matter with an aerodynamic equivalent diameter of 2.5 mm or less in ambient air (PM2.5) has become a global public and environmental problem, and the control of the PM2.5 concentration in air is an urgent problem. PM2.5 can easily penetrate the skin, activating the inflammatory response in skin, unbalancing the skin barrier function, and inducing skin aging. Hyperpigmentation is the main manifestation of skin aging and has a considerable impact on quality of life worldwide. To date, no research on the influence of PM2.5 on hyperpigmentation has been conducted. Here, we illustrate that PM2.5 can induce melanogenesis in vivo and in vitro by regulating TYR, TYRP1, TYRP2, and MITF expression via AhR/ MAPK signaling activation. Furthermore, PM2.5 increased a-MSH paracrine levels, which in turn promote hyperpigmentation. Our results provide a deeper understanding of how PM2.5 disrupts skin homeostasis and function. Treatment with AhR antagonists may be a potential therapeutic strategy for hyperpigmentation induced by PM2.5. (c) 2021 Elsevier Ltd. All rights reserved.
引用
收藏
页数:9
相关论文
共 40 条
  • [1] Aryl Hydrocarbon Receptor Activation Contributes to Benzanthrone-Induced Hyperpigmentation via Modulation of Melanogenic Signaling Pathways
    Abbas, Sabiya
    Alam, Shamshad
    Singh, Krishna P.
    Kumar, Mahadeo
    Gupta, Shailendra K.
    Ansari, Kausar M.
    [J]. CHEMICAL RESEARCH IN TOXICOLOGY, 2017, 30 (02) : 625 - 634
  • [2] Global air quality and pollution
    Akimoto, H
    [J]. SCIENCE, 2003, 302 (5651) : 1716 - 1719
  • [3] The aryl hydrocarbon receptor complex and the control of gene expression
    Beischlag, Timothy V.
    Morales, J. Luis
    Hollingshead, Brett D.
    Perdew, Gary H.
    [J]. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 2008, 18 (03): : 207 - 250
  • [4] Aryl hydrocarbon receptor (AHR): From selected human target genes and crosstalk with transcription factors to multiple AHR functions
    Bock, Karl Walter
    [J]. BIOCHEMICAL PHARMACOLOGY, 2019, 168 : 65 - 70
  • [5] Particulate Matter Air Pollution and Cardiovascular Disease An Update to the Scientific Statement From the American Heart Association
    Brook, Robert D.
    Rajagopalan, Sanjay
    Pope, C. Arden, III
    Brook, Jeffrey R.
    Bhatnagar, Aruni
    Diez-Roux, Ana V.
    Holguin, Fernando
    Hong, Yuling
    Luepker, Russell V.
    Mittleman, Murray A.
    Peters, Annette
    Siscovick, David
    Smith, Sidney C., Jr.
    Whitsel, Laurie
    Kaufman, Joel D.
    [J]. CIRCULATION, 2010, 121 (21) : 2331 - 2378
  • [6] Signaling Pathways in Melanogenesis
    D'Mello, Stacey A. N.
    Finlay, Graeme J.
    Baguley, Bruce C.
    Askarian-Amiri, Marjan E.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (07)
  • [7] Ding AS, 2017, SCI REP-UK, V7, DOI [10.1038/s41598-017-12710-y, 10.1038/s41598-017-15295-8]
  • [8] Skin inflammation induced by ambient particulate matter in China
    Dong, Yin-mao
    Liao, Lian-ying
    Li, Li
    Yi, Fan
    Meng, Hong
    He, Yi-fan
    Guo, Miao-miao
    [J]. SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 682 : 364 - 373
  • [9] The Aryl Hydrocarbon Receptor in Barrier Organ Physiology, Immunology, and Toxicology
    Esser, Charlotte
    Rannug, Agneta
    [J]. PHARMACOLOGICAL REVIEWS, 2015, 67 (02) : 259 - 279
  • [10] Functions of the aryl hydrocarbon receptor in the skin
    Esser, Charlotte
    Bargen, Imke
    Weighardt, Heike
    Haarmann-Stemmann, Thomas
    Krutmann, Jean
    [J]. SEMINARS IN IMMUNOPATHOLOGY, 2013, 35 (06) : 677 - 691