Haploidentical hematopoietic stem cell transplantation with αβTCR+/CD19+depletion in pediatric patients with malignant and non-malignant disorders

被引：5

作者：

Bielorai, Bella ^{[1
,2
]}

Jacoby, Elad ^{[1
,2
]}

Varda-Bloom, Nira ^{[3
]}

Hutt, Daphna ^{[1
]}

Churi, Chaim ^{[1
]}

Vernitsky, Helly ^{[3
]}

Toren, Amos ^{[1
,2
]}

机构：

[1] Edmond & Lily Safra Childrens Hosp, Sheba Med Ctr, Dept Pediat Hematol Oncol & BMT, Ramat Gan, Israel

[2] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel

[3] Sheba Med Ctr, Inst Hematol, Ramat Gan, Israel

来源：

BONE MARROW TRANSPLANTATION | 2019年 / 54卷 / Suppl 2期

关键词：

TCR-ALPHA-BETA; ACUTE-LEUKEMIA; T-CELL; DEPLETION; CHILDREN; DONORS; IMMUNODEFICIENCY; ALLOGRAFTS; BLOOD;

D O I：

10.1038/s41409-019-0607-0

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Haploidntical hematopoietic stem cell transplantation has been increasingly used in recent years for patients without a matched donor. The alpha beta TCR+/CD19+ depletion technique provide a graft that is enriched with CD34 cells, gamma delta-T-cells and natural killer. The current experience with alpha beta TCR+/CD19+ depleted grafts in pediatric patients with malignant and nonmalignant disorders, demonstrated rapid engraftment, improved immune reconstitution and low risk of GVHD. Future studies will need to define the optimal conditioning regimen in order to improve transplant outcome.

引用

页码：694 / 697

页数：4

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