Cancer Metabolism: Current Understanding and Therapies

被引：173

作者：

Counihan, Jessica L. ^{[1
,2
,3
,4
]}

Grossman, Elizabeth A. ^{[1
,2
,3
,4
]}

Nomura, Daniel K. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Dept Nutr Sci, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Dept Toxicol, Berkeley, CA 94720 USA

来源：

CHEMICAL REVIEWS | 2018年 / 118卷 / 14期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

FATTY-ACID SYNTHASE; COA-CARBOXYLASE-ALPHA; PROTEIN; 90; INHIBITOR; ATP CITRATE LYASE; CELL LUNG-CANCER; INDOLEAMINE 2,3-DIOXYGENASE EXPRESSION; GERANYLGERANYLTRANSFERASE-I INHIBITORS; ORNITHINE-DECARBOXYLASE ACTIVITY; ACUTE LYMPHOBLASTIC-LEUKEMIA; INTRACELLULAR FOLATE POOLS;

D O I：

10.1021/acs.chemrev.7b00775

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dysregulation of cancer cell metabolism contributes to abnormal cell growth, the biological end point of cancer. We review here numerous affected oncogenes and metabolic pathways common in cancer and how they contribute to cancer pathogenesis and malignancy. This review also discusses various pharmacological manipulations that take advantage of these metabolic abnormalities and the current targeted therapies that have arisen from this research.

引用

页码：6893 / 6923

页数：31

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