Copper-catalyzed vinylation of hydrazides. A regioselective entry to highly substituted pyrroles

被引：106
作者：
Rivero, Marta Rodriguez [1 ]
Buchwald, Stephen L. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 06期
关键词：
D O I：
10.1021/ol062978s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A modular route to highly substituted pyrroles has been developed. This transformation consists of two sequential copper-catalyzed vinylations of bis-Boc-hydrazine followed by thermal rearrangement/cyclization. A wide variety of functionalized pyrroles can be prepared in a selective manner from simple and easily accessible precursors.
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页码：973 / 976
页数：4
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