Is Inflammatory Bowel Disease a Risk Factor for Early Atherosclerosis?

被引：67

作者：

Dagli, Necati ^{[1
]}

Poyrazoglu, Orhan K. ^{[3
]}

Dagli, A. Ferda ^{[4
]}

Sahbaz, Fatih ^{[2
]}

Karaca, Ilgin ^{[1
]}

Kobat, M. Ali ^{[1
]}

Bahcecioglu, Ibrahim H. ^{[3
]}

机构：

[1] Firat Univ, Dept Cardiol, TR-23100 Elazig, Turkey

[2] Firat Univ, Dept Internal Med, TR-23100 Elazig, Turkey

[3] Firat Univ, Dept Gastroenterol, TR-23100 Elazig, Turkey

[4] Firat Univ, Dept Pathol, TR-23100 Elazig, Turkey

来源：

ANGIOLOGY | 2010年 / 61卷 / 02期

关键词：

atherosclerosis; homocysteine; inflammation; inflammatory bowel disease; intima media thickness; insulin resistance; INTIMA-MEDIA THICKNESS; ACCELERATED ATHEROSCLEROSIS; INSULIN-RESISTANCE; HYPERHOMOCYSTEINEMIA; PATHOGENESIS; SENSITIVITY; COAGULATION; STIFFNESS; GLUCOSE;

D O I：

10.1177/0003319709333869

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Objectives: Chronic inflammatory diseases are associated with an accelerated atherosclerotic process. Recent studies have discussed whether inflammatory bowel diseases (IBDs) can predict early atherosclerosis. We investigated this possibility. Methods: The study consisted of IBD cases (group 1, n = 40) and healthy persons (group 2, n = 40). The IBD group was selected so as not to have vascular disease or the presence of established major cardiovascular risk factors. Results: Group 1 cases showed a significant increase in carotid intima media thickness (cIMT; P = .01). Carotid artery stiffness was impaired in group 1 (P = .03) and high-sensitivity C-reactive protein (hsCRP), homeostasis model assessment of insulin resistance (HOMA-IR), and homocysteine (Hyc) were higher in group 1 patients (P = .02, P = .03, P = .05). Conclusions: Inflammatory bowel disease patients have an increased risk of early atherosclerosis as shown by greater values of cIMT, carotid artery stiffness, Hyc, hsCRP, and insulin resistance.

引用

页码：198 / 204

页数：7

共 38 条

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