Over-the-counter Drug Induced Autoimmune Hepatitis

被引：2

作者：

Takeda, Karin ^{[1
]}

Oda, Masaya ^{[2
]}

Okada, Takemichi ^{[3
]}

Yamazaki, Hitoshi ^{[4
]}

Ohbu, Makoto ^{[5
]}

Watanabe, Masaaki ^{[1
]}

Yokomori, Hiroaki ^{[1
]}

机构：

[1] Kitasato Univ, Med Ctr, Dept Internal Med, Tokyo, Japan

[2] Int Univ Hlth & Welf, Organized Ctr Clin Med, Tokyo, Japan

[3] Kitasato Univ, Med Ctr, Dept Radiol, Tokyo, Japan

[4] Kitasato Univ, Med Ctr, Div Pathol, Tokyo, Japan

[5] Kitasato Univ, Sch Allied Hlth Sci, Dept Pathol, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2016年 / 55卷 / 10期

关键词：

drug-induced hepatic injury; autoimmune hepatitis; over-the-counter drug; immunohistochemistry; electron microscopy; INDUCED LIVER-INJURY; DIAGNOSIS;

D O I：

10.2169/internalmedicine.55.5509

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 64-year-old man seeking treatment for a common cold was admitted to our hospital due to symptoms of general fatigue and liver dysfunction. A thorough history review revealed that the patient had recently started taking an over-the-counter (OTC) drug. Drug-induced lymphocyte stimulation tests were positive. Serum markers for autoimmune hepatitis (AIH) were particularly elevated. Liver biopsy revealed spotty necrosis and ceroid-pigmented Kupffer cells and piecemeal necrosis with multiple plasma cells. He responded to corticosteroids, thus suggesting the presence of an immune-mediated component associated with the liver injury. Liver injury after using OTCs should be included in the differential diagnosis for chronic hepatitis with features of AIH.

引用

页码：1293 / 1297

页数：5

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