Synthesis of 2'-C-Methyl Ribonucleoside Analogues with Modified Heterocyclic Base Moieties

被引：7
作者：
Kim, Myong Jung [1 ]
机构：
[1] Fdn Appl Mol Evolut, Gainesville, FL 32604 USA
来源：
SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 20期
关键词：
Antiviral agent; HCV; 2'-C-methyl nucleoside; HEPATITIS-C-VIRUS; DEPENDENT RNA-POLYMERASE; WEST-NILE VIRUS; IN-VITRO; RIBAVIRIN; REPLICATION; INHIBITION; NUCLEOSIDE; NS5B;
D O I：
10.1080/00397910903349984
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Recently, 2'-C-methyl nucleoside analogues have been reported to exhibit potent anti-hepatitis C virus (HCV) activity through inhibition of HCV RNA replication without significant cytotoxicity. As a part of our continuous efforts of searching for novel antiviral agents, we now report the synthesis of heterobase-modified 2'-C-methyl ribonucleoside analogues.
引用
收藏
页码：2988 / 2999
页数：12
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