NF-κB Members Left Home: NF-κB-Independent Roles in Cancer

被引：41

作者：

Colomer, Carlota ^{[1
]}

Marruecos, Laura ^{[1
]}

Vert, Anna ^{[1
]}

Bigas, Anna ^{[1
]}

Espinosa, Lluis ^{[1
]}

机构：

[1] CIBERONC Inst Hosp Mar Invest Med IMIM, Stem Cells & Canc Res Lab, Barcelona 08003, Spain

来源：

BIOMEDICINES | 2017年 / 5卷 / 02期

关键词：

Cancer; NF-kappa B; Non-conventional pathways; IKKs; I kappa Bs; ALPHA-DEPENDENT TRANSCRIPTION; NUCLEAR IKK ACTIVITY; HEPATOCELLULAR-CARCINOMA; PROSTATE-CANCER; KINASE-ALPHA; LINKS INFLAMMATION; INSULIN-RESISTANCE; COLORECTAL-CANCER; SIGNALING PATHWAY; MAMMALIAN TARGET;

D O I：

10.3390/biomedicines5020026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclear factor-kappa B (NF-kappa B) has been long considered a master regulator of inflammation and immune responses. Additionally, aberrant NF-kappa B signaling has been linked with carcinogenesis in many types of cancer. In recent years, the study of NF-kappa B members in NF-kappa B unrelated pathways provided novel attractive targets for cancer therapy, specifically linked to particular pathologic responses. Here we review specific functions of I kappa B kinase complexes (IKKs) and I kappa Bs, which have distinctly tumor promoting or suppressing activities in cancer. Understanding how these proteins are regulated in a tumor-related context will provide new opportunities for drug development.

引用

页数：11

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