Pemetrexed in advanced non-small-cell lung cancer

被引：46

作者：

Fuld, Alexander D. ^{[1
]}

Dragnev, Konstantin H. ^{[1
]}

Rigas, James R. ^{[1
]}

机构：

[1] Dartmouth Hitchcock Med Ctr, Norris Cotton Canc Ctr, Lebanon, NH 03756 USA

来源：

EXPERT OPINION ON PHARMACOTHERAPY | 2010年 / 11卷 / 08期

关键词：

PHASE-II TRIAL; FRONT-LINE THERAPY; MALIGNANT PLEURAL MESOTHELIOMA; CONTINUAL REASSESSMENT METHOD; GEMCITABINE PLUS CARBOPLATIN; PLATINUM-BASED CHEMOTHERAPY; PREVIOUSLY TREATED PATIENTS; THYMIDYLATE-SYNTHASE; MULTITARGETED ANTIFOLATE; 1ST-LINE TREATMENT;

D O I：

10.1517/14656566.2010.482560

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Areas covered in this review: Currently available published data on mechanism of action, pharmacokinetics, safety and efficacy of pemetrexed in the treatment of advanced NSCLC are described. Peer-reviewed publications on the development of pemetrexed and its clinical use in NSCLC were reviewed (1995 - 2009). What the reader will gain: Pemetrexed is a multitargeted antifolate cytotoxic agent. Key Phase II and Phase III trials are described that have shown pemetrexed's efficacy in both the first- and second-line treatment of advanced NSCLC. The efficacy of pemetrexed seems to vary between squamous and nonsquamous histologies. Possible reasons for this are explored. Additionally, the potential role of pemetrexed in maintenance therapy is discussed. Take home message: Pemetrexed is an effective treatment for advanced NSCLC, with an overall favorable toxicity profile. There is growing evidence that, in patients treated with pemetrexed, nonsquamous tumors have improved outcomes compared to squamous cell tumors. Pemetrexed may also have a role in maintenance therapy for NSCLC.

引用

页码：1387 / 1402

页数：16

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