Novel Bioactive Glass-Modified Hybrid Composite Resin: Mechanical Properties, Biocompatibility, and Antibacterial and Remineralizing Activity

被引:21
作者
Han, Xiao [1 ,2 ]
Chen, Yan [3 ]
Jiang, Qian [4 ]
Liu, Xin [5 ]
Chen, Yaming [1 ,2 ]
机构
[1] Nanjing Med Univ, Jiangsu Key Lab Oral Dis, Nanjing, Peoples R China
[2] Nanjing Med Univ, Dept Polyclin, Affiliated Hosp Stomatol, Nanjing, Peoples R China
[3] Fudan Univ, Shanghai Stomatol Hosp, Dept Periodontol, Shanghai Key Lab Craniomaxillofacial Dev & Dis, Shanghai, Peoples R China
[4] Shanghai Jiao Tong Univ, Dept Oral Surg, Shanghai Peoples Hosp 9,Shanghai Key Lab Stomatol, Sch Med,Coll Stomatol,Natl Ctr Stomatol,Natl Clin, Shanghai, Peoples R China
[5] Shanghai Jiao Tong Univ, Dept Dent Mat,Shanghai Key Lab Stomatol, Shanghai Biomat Res & Testing Ctr,Natl Clin Res C, Shanghai Peoples Hosp 9,Sch Med,Coll Stomatol,Nat, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
composite resin; bioactive glass; antibacterial activity; remineralization; biocompatibility; DENTAL COMPOSITES; RESTORATIONS; LONGEVITY; 45S5; CYTOTOXICITY; TITANIUM;
D O I
10.3389/fbioe.2021.661734
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Secondary caries seriously limits the lifetime of composite resin. However, integrating all desirable properties (i.e., mechanical, antibacterial, bioactivity, and biocompatibility) into one composite resin is still challenging. Herein, a novel bioactive glass (BAG)-modified hybrid composite resin has been successfully developed to simultaneously achieve excellent mechanical properties, good biocompatibility, and antibacterial and remineralizing capabilities. When the mass fractions of BAG particles were added from 8 to 23 wt %, the original mechanical properties of the composite resin, including flexural strength and compressive strength, were not obviously affected without compromising the degree of conversion. Although the BAG incorporation of mass fractions of 16 wt % to 23 wt % in composite resins reduced cell viability, the viability could be recovered to normal by adjusting the pH value. Moreover, the BAG-modified composite resins that were obtained showed good antibacterial effects against Streptococcus mutans and enhanced remineralizing activity on demineralized dentin surfaces with increasing incorporation of BAG particles. The possible mechanisms for antibacterial and remineralizing activity might be closely related to the release of bioactive ions (Ca2+, Si4+), suggesting that its antibacterial and biological properties can be controlled by modulating the amounts of bioactive ions. The capability to balance the mechanical properties, cytotoxicity, antibacterial activity, and bioactivity makes the BAG-modified composite resin a promising prospect for clinical application. Our findings provide insight into better design and intelligent fabrication of bioactive composite resins.
引用
收藏
页数:15
相关论文
共 55 条
[1]   Bioactive glass composite for orthodontic adhesives - Formation and characterisation of apatites using MAS-NMR and SEM [J].
Al-eesa, N. A. ;
Karpukhina, N. ;
Hill, R. G. ;
Johal, A. ;
Wong, F. S. L. .
DENTAL MATERIALS, 2019, 35 (04) :597-605
[2]   A Chemical Approach to Optimizing Bioactive Glass Dental Composites [J].
Aponso, S. ;
Ummadi, J. G. ;
Davis, H. ;
Ferracane, J. ;
Koley, D. .
JOURNAL OF DENTAL RESEARCH, 2019, 98 (02) :194-199
[3]   Does the Addition of Zinc Oxide Nanoparticles Improve the Antibacterial Properties of Direct Dental Composite Resins? A Systematic Review [J].
Arun, Divya ;
Adikari Mudiyanselage, Dulanja ;
Gulam Mohamed, Rumana ;
Liddell, Michael ;
Monsur Hassan, Nur Mohammad ;
Sharma, Dileep .
MATERIALS, 2021, 14 (01) :1-15
[4]   Longevity of posterior resin composite restorations in adults - A systematic review [J].
Astvaldsdottir, Alfheidur ;
Dagerhamn, Jessica ;
van Dijken, Jan W. V. ;
Naimi-Akbar, Aron ;
Sandborgh-Englund, Gunilla ;
Tranaeus, Sofia ;
Nilsson, Mikael .
JOURNAL OF DENTISTRY, 2015, 43 (08) :934-954
[5]   Evaluation of new treatment for incipient enamel demineralization using 45S5 bioglass [J].
Bakry, A. S. ;
Takahashi, H. ;
Otsuki, M. ;
Tagami, J. .
DENTAL MATERIALS, 2014, 30 (03) :314-320
[6]   The effect of a bioglass paste on enamel exposed to erosive challenge [J].
Bakry, Ahmed Samir ;
Marghalani, Hanadi Y. ;
Amin, Omayma A. ;
Tagami, Junji .
JOURNAL OF DENTISTRY, 2014, 42 (11) :1458-1463
[7]   Toward dental caries: Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials [J].
Balhaddad, Abdulrahman A. ;
Kansara, Anmar A. ;
Hidan, Denise ;
Weir, Michael D. ;
Xu, Hockin H. K. ;
Melo, Mary Anne S. .
BIOACTIVE MATERIALS, 2019, 4 :43-55
[8]   Dentin pretreatment with 45S5 and niobophosphate bioactive glass: Effects on pH, antibacterial, mechanical properties of the interface and microtensile bond strength [J].
Bauer, Jose ;
Silva e Silva, Allana ;
Carvalho, Edilausson Moreno ;
Campos Ferreira, Paulo Vitor ;
Carvalho, Ceci Nunes ;
Manso, Adriana Pigozzo ;
Carvalho, Ricardo Marins .
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 2019, 90 :374-380
[9]   Novel low-shrinkage-stress nanocomposite with remineralization and antibacterial abilities to protect marginal enamel under biofilm [J].
Bhadila, Ghalia ;
Wang, Xiaohong ;
Zhou, Wen ;
Menon, Deepak ;
Melo, Mary Ann S. ;
Montaner, Silvia ;
Oates, Thomas W. ;
Weir, Michael D. ;
Sun, Jirun ;
Xu, Hockin H. K. .
JOURNAL OF DENTISTRY, 2020, 99
[10]   Designing dental composites with bioactive and bactericidal properties [J].
Chatzistavrou, Xanthippi ;
Velamakanni, Saalini ;
DiRenzo, Kyle ;
Lefkelidou, Anna ;
Fenno, J. Christopher ;
Kasuga, Toshihiro ;
Boccaccini, Aldo R. ;
Papagerakis, Petros .
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2015, 52 :267-272