Probing the role of the vestibular system in motivation and reward-based attention

被引:15
作者
Blini, Elvio [1 ,2 ,5 ]
Tilikete, Caroline [1 ,2 ,3 ,5 ]
Farne, Alessandro [1 ,2 ,4 ,5 ]
Hadj-Bouziane, Fadila [1 ,2 ,5 ]
机构
[1] Lyon Neurosci Res Ctr CRNL, CNRS, Integrat Multisensory Percept Act & Cognit Team I, INSERM,,1028,UMR5292, Lyon, France
[2] Univ Lyon 1, Lyon, France
[3] Hop Neurol & Neurochirurg P Wertheimer, Hosp Civils Lyon, Neuroophthalmol & Neurocognit, Bron, France
[4] Hosp Civils Lyon, Neuroimmers & Mouvement & Handicap, Lyon, France
[5] Lyon Neurosci Res Ctr, CNRS, INSERM, ImpAct Team,UMR5292,U1028, 16 Ave Doyen Lepine, F-69500 Bron, France
基金
欧盟地平线“2020”;
关键词
Attentional capture; Reward; Motivation; Spatial attention; Brain stimulation; Vestibular stimulation; Galvanic vestibular stimulation; Anterior cingulate cortex; Addiction; ANTERIOR CINGULATE CORTEX; SPATIAL ATTENTION; CALORIC STIMULATION; FUNCTIONAL MRI; ADDICTION; PRIORITY; NEGLECT; CONNECTIONS; PARIETAL; CAPTURE;
D O I
10.1016/j.cortex.2018.02.009
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The vestibular system has widespread connections in the central nervous system. Several activation loci following vestibular stimulations have been notably reported in deep, limbic areas that are otherwise difficult to reach and modulate in healthy subjects. Following preliminary evidence, suggesting that such stimulations might affect mood and affective processing, we wondered whether the vestibular system is also involved in motivation. Evolutionary accounts suggest that visuo-vestibular mismatches might have a role in preventing the search for and exploitation of goods that previously resulted in aversive reactions, as they would be a fine warning signal which follows the contact with or ingestion of noxious neurotoxins. The first question was thus whether vestibular stimulation alters sensitivity to reward. Secondly, we sought to assess whether attention is allocated in space differently when cued by highly motivational stimuli, and if this interplay is further modulated by the vestibular system. In order to evaluate both motivational and attentional assets, we administered a Posner-like cueing task to 30 healthy subjects concurrently receiving sham or galvanic vestibular stimulation (GVS; Left-Anodal and Right-Anodal configurations). The participants had to discriminate targets appearing in either exogenously cued or uncued locations (50% validity); cues predicted the amount of points (0, 2, or 10) and thus money that they could earn for a correct response. The results highlight a robust inhibition of return (IOR) (faster responses for invalidly-cued targets) which was not modulated by different levels of reward or GVS. Across all stimulation sessions, rewards exerted a powerful beneficial effect over performance: reaction times were faster when rewards were at stake. However, this effect was largest in sham, but greatly reduced in GVS conditions, most notably with the Right-Anodal configuration. This is the first evidence for a decreased sensitivity to rewards causally induced by a perturbation of the vestibular system. While future studies will shed light on its neural underpinnings and clinical implications, here we argue that GVS could be a safe and promising way to enrich our understanding of reward processes and eventually tackle the management of patients with aberrant sensitivity to rewards. (C) 2018 The Author(s). Published by Elsevier Ltd.
引用
收藏
页码:82 / 99
页数:18
相关论文
共 110 条
  • [1] Early and Phasic Cortical Metabolic Changes in Vestibular Neuritis Onset
    Alessandrini, Marco
    Pagani, Marco
    Napolitano, Bianca
    Micarelli, Alessandro
    Candidi, Matteo
    Bruno, Ernesto
    Chiaravalloti, Agostino
    Di Pietro, Barbara
    Schillaci, Orazio
    [J]. PLOS ONE, 2013, 8 (03):
  • [2] Reward encoding in the monkey anterior cingulate cortex
    Amiez, C.
    Joseph, J. P.
    Procyk, E.
    [J]. CEREBRAL CORTEX, 2006, 16 (07) : 1040 - 1055
  • [3] Value-driven attentional priority signals in human basal ganglia and visual cortex
    Anderson, Brian A.
    Laurent, Patryk A.
    Yantis, Steven
    [J]. BRAIN RESEARCH, 2014, 1587 : 88 - 96
  • [4] Value-driven attentional and oculomotor capture during goal-directed, unconstrained viewing
    Anderson, Brian A.
    Yantis, Steven
    [J]. ATTENTION PERCEPTION & PSYCHOPHYSICS, 2012, 74 (08) : 1644 - 1653
  • [5] Value-driven attentional capture
    Anderson, Brian A.
    Laurent, Patryk A.
    Yantis, Steven
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (25) : 10367 - 10371
  • [6] [Anonymous], 2017, EASILY INSTALL LOAD
  • [7] [Anonymous], ARXIV150604967STAT
  • [8] [Anonymous], R LANG ENV STAT COMP
  • [9] [Anonymous], 2016, ggplot2: Elegant Graphics for Data Analysis
  • [10] Augustine J R, 1985, Neurol Res, V7, P2