Nivolumab-Induced Alopecia Areata: A Case Report and Literature Review

被引:9
作者
Kim, Ki-Hun [1 ]
Sim, Woo-Young [1 ]
Lew, Bark-Lynn [1 ]
机构
[1] Kyung Hee Univ, Dept Dermatol, Sch Med, Seoul, South Korea
关键词
Alopecia areata; Nivolumab;
D O I
10.5021/ad.2021.33.3.284
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Nivolumab (anti-PD-1) currently used in many cancers. With the usage of nivolumab increased, many cutaneous side effects were reported including maculopapular rash, lichenoid reactions, vitiligo, bullous disorders, psoriasis exacerbation, and alopecia areata (AA). Here, we report AA after nivolumab for treatment of hepatocellular carcinomas (HCC). A 55-year-old male presented with multiple hairless patch from 1 month ago. He suffered HCC and treated with nivolumab for 6 months after hepatectomy. He treated for hair loss with triamcinolone intra-lesional injection without improvement. We performed skin biopsy on the scalp. Histopathologic findings revealed decreased of hair follicles on the horizontal section with lymphocyte infiltration on the perifollicular area on the vertical section. Clinicopathologic findings were agreed with AA. Considering lack of previous history of AA and hairless patches with 6 months after nivolumab injection, we diagnosed him as nivolumab induced AA. Treatment included topical steroid, and minoxidil. No regrowth of hair was noted after 4 months of follow-up. Nivolimumab induced AA is rare side effect. Pathogenesis of nivolumab induced AA remain unclear. But our case is likely related to nivolumab, known to induce immune related adverse events, and given in the delay of a few months between introduction and the occurrence of the hair loss. Here, we reports nivolmumab induced AA; rare side effect.
引用
收藏
页码:284 / 288
页数:5
相关论文
共 50 条
[1]   Nivolumab-induced myositis: A case report and a literature review [J].
Bourgeois-Vionnet, Julie ;
Joubert, Bastien ;
Bernard, Emilien ;
Sia, Marie Angele ;
Pante, Vanessa ;
Fabien, Nicole ;
Honnorat, Jerome ;
Streichenberger, Nathalie .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2018, 387 :51-53
[2]   Nivolumab-induced aplastic anemia: A case report and literature review [J].
Comito, Rachel R. ;
Badu, Lynette A. ;
Forcello, Nicholas .
JOURNAL OF ONCOLOGY PHARMACY PRACTICE, 2019, 25 (01) :221-225
[3]   Nivolumab-Induced Cytokine Release Syndrome: A Case Report and Literature Review [J].
Ntwali, Francis ;
Gilliaux, Quentin ;
Honore, Patrick M. .
AMERICAN JOURNAL OF CASE REPORTS, 2024, 25
[4]   Conservative management of nivolumab-induced pericardial effusion: a case report and review of literature [J].
Shagufta Shaheen ;
Hamid Mirshahidi ;
Gayathri Nagaraj ;
Chung-Tsen Hsueh .
Experimental Hematology & Oncology, 7
[5]   Conservative management of nivolumab-induced pericardial effusion: a case report and review of literature [J].
Shaheen, Shagufta ;
Mirshahidi, Hamid ;
Nagaraj, Gayathri ;
Hsueh, Chung-Tsen .
EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2018, 7
[6]   Nivolumab-induced Myocarditis Successfully Treated with Corticosteroid Therapy: A Case Report and Review of the Literature [J].
Matsuo, Keisuke ;
Ishiguro, Takashi ;
Najama, Takatomo ;
Shimizu, Yoshihiko ;
Kobayashi, Yasuhito ;
Mutou, Makoto .
INTERNAL MEDICINE, 2019, 58 (16) :2367-2372
[7]   Nivolumab-induced severe bullous pemphigoid in a patient with renal cancer: a case report and literature review [J].
Wu, Xiaorong ;
Palvai, Sreekanth ;
Jalil, Awais .
JOURNAL OF CANCER METASTASIS AND TREATMENT, 2020, 6
[8]   Nivolumab-Induced Diabetic Ketoacidosis: A Case Report [J].
Giese, Drake ;
Elkhedr, Ali ;
Jnaneswaran, Geethu ;
Ernste, Katherine M. .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (07)
[9]   Nivolumab-induced fatal myocarditis: A case report [J].
Bharathidasan, Kavya ;
Abdelnabi, Mahmoud ;
Abdelmalek, John ;
Sekhon, Jasmine ;
Butler, William ;
Quirch, Miguel ;
Sosa, Erwin Argueta .
CLINICAL CASE REPORTS, 2023, 11 (05)
[10]   Nivolumab-induced Diaphragm Dysfunction: A Case Report [J].
Schouwenburg, Jasper .
INDIAN JOURNAL OF CRITICAL CARE MEDICINE, 2023, 27 (02) :147-148