Targeting Liposomes Toward Novel Pediatric Anticancer Therapeutics

被引：25

作者：

Federman, Noah ^{[1
,2
,3
,4
]}

Denny, Christopher T. ^{[2
,3
,4
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Mattel Childrens Hosp,Gwynne Hazen Cherry Mem Lab, Jonsson Comprehens Canc Ctr,Div Pediat Hematol On, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Mattel Childrens Hosp, Gwynne Hazen Cherry Mem Labs, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Inst Mol Biol, UCLSs Johnsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA

[4] Calif NanoSyst Inst, Los Angeles, CA 90095 USA

来源：

PEDIATRIC RESEARCH | 2010年 / 67卷 / 05期

关键词：

TRANSFERRIN-COUPLED LIPOSOMES; PHASE-I TRIAL; DRUG-DELIVERY; SOLID TUMORS; VASCULAR-PERMEABILITY; MEDIATED ENDOCYTOSIS; PEGYLATED LIPOSOMES; CIRCULATION TIME; GENE-TRANSFER; CANCER-CELLS;

D O I：

10.1203/PDR.0b013e3181d601c5

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Although modern multimodal treatment of pediatric cancer has resulted in long-term cure of many patients, clinical success has come with significant acute and chronic morbidity. Targeted therapy using anticancer agents encapsulated in nanoparticles holds considerable promise in further improving efficacy and reducing toxic side effects. This review highlights the current strategies toward developing such therapeutic tools with an emphasis on using liposomes as flexible delivery vehicles. Potential strengths and technical difficulties encountered in advancing this platform are summarized. Critical functional determinants of nanoparticle delivery systems and future strategies to improve efficacy and specificity are described. (Pediatr Res 67: 514-519, 2010)

引用

页码：514 / 519

页数：6

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