Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery

被引：111

作者：

Choi, Hyung Woo ^{[1
]}

Kim, Jihoon ^{[1
]}

Kim, Jinhwan ^{[2
]}

Kim, Yonghwi ^{[1
]}

Song, Hyun Beom ^{[3
]}

Kim, Jeong Hun ^{[3
]}

Kim, Kimoon ^{[1
,2
]}

Kim, Won Jong ^{[1
,2
]}

机构：

[1] Inst for Basic Sci Korea, Ctr Self Assembly & Complex, Pohang 37673, South Korea

[2] Pohang Univ Sci & Technol POSTECH, Dept Chem, Pohang 37673, South Korea

[3] Seoul Natl Univ, Grad Sch, Dept Biomed Sci, Seoul 03080, South Korea

来源：

ACS NANO | 2016年 / 10卷 / 04期

关键词：

nitric oxide delivery; calcium phosphate; pH-jump reagent; gatekeeper; corneal wound healing; MESOPOROUS SILICA NANOPARTICLES; CALCIUM-PHOSPHATE NANOPARTICLES; CONTROLLED DRUG-DELIVERY; CONTROLLED-RELEASE; IN-VITRO; CHEMISTRY; DONORS; TRANSFECTION; MECHANISM; EFFICACY;

D O I：

10.1021/acsnano.5b07483

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report herein the design of a light-responsive gatekeeper for smart nitric oxide (NO) delivery. The gatekeeper is composed of a pH-jump reagent as an intermediary of stimulus and a calcium phosphate (CaP) coating as a shielding layer for NO release. The light irradiation and subsequent acid generation are used as triggers for uncapping the gatekeeper and releasing NO. The acids generated from a light-activated pH-jump agent loaded in the mesoporous nanoparticles accelerated the degradation of the CaPcoating layers on the nanoparticles, facilitating the light-responsive NO release from diazeniumdiolate by exposing a NO donor to physiological conditions. Using the combination of the pH-jump reagent and CaP coating, we successfully developed a light-responsive gatekeeper system for spatiotemporal-controlled NO delivery.

引用

页码：4199 / 4208

页数：10

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