Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery

被引：111

作者：

Choi, Hyung Woo ^{[1
]}

Kim, Jihoon ^{[1
]}

Kim, Jinhwan ^{[2
]}

Kim, Yonghwi ^{[1
]}

Song, Hyun Beom ^{[3
]}

Kim, Jeong Hun ^{[3
]}

Kim, Kimoon ^{[1
,2
]}

Kim, Won Jong ^{[1
,2
]}

机构：

[1] Inst for Basic Sci Korea, Ctr Self Assembly & Complex, Pohang 37673, South Korea

[2] Pohang Univ Sci & Technol POSTECH, Dept Chem, Pohang 37673, South Korea

[3] Seoul Natl Univ, Grad Sch, Dept Biomed Sci, Seoul 03080, South Korea

来源：

ACS NANO | 2016年 / 10卷 / 04期

关键词：

nitric oxide delivery; calcium phosphate; pH-jump reagent; gatekeeper; corneal wound healing; MESOPOROUS SILICA NANOPARTICLES; CALCIUM-PHOSPHATE NANOPARTICLES; CONTROLLED DRUG-DELIVERY; CONTROLLED-RELEASE; IN-VITRO; CHEMISTRY; DONORS; TRANSFECTION; MECHANISM; EFFICACY;

D O I：

10.1021/acsnano.5b07483

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report herein the design of a light-responsive gatekeeper for smart nitric oxide (NO) delivery. The gatekeeper is composed of a pH-jump reagent as an intermediary of stimulus and a calcium phosphate (CaP) coating as a shielding layer for NO release. The light irradiation and subsequent acid generation are used as triggers for uncapping the gatekeeper and releasing NO. The acids generated from a light-activated pH-jump agent loaded in the mesoporous nanoparticles accelerated the degradation of the CaPcoating layers on the nanoparticles, facilitating the light-responsive NO release from diazeniumdiolate by exposing a NO donor to physiological conditions. Using the combination of the pH-jump reagent and CaP coating, we successfully developed a light-responsive gatekeeper system for spatiotemporal-controlled NO delivery.

引用

页码：4199 / 4208

页数：10

共 63 条

[1]

ARAIE M, 1990, INVEST OPHTH VIS SCI, V31, P2191

[2] Nitric oxide photocaging platinum nanoparticles with anticancer potential [J].

Barone, Mariarita ;

Sciortino, Maria T. ;

Zaccaria, Daniela ;

Mazzaglia, Antonino ;

Sortino, Salvatore .

JOURNAL OF MATERIALS CHEMISTRY, 2008, 18 (45) :5531-5536

[3] Nitric oxide and the immune response [J].

Bogdan, C .

NATURE IMMUNOLOGY, 2001, 2 (10) :907-916

[4] Effects of the COOH-terminal tripeptide α-MSH11-13 on corneal epithelial wound healing:: Role of nitric oxide [J].

Bonfiglio, Vincenza ;

Camillieri, Giovanni ;

Avitabile, Teresio ;

Leggio, Gian Marco ;

Drago, Filippo .

EXPERIMENTAL EYE RESEARCH, 2006, 83 (06) :1366-1372

[5] The basic science of wound healing [J].

Broughton, George, II ;

Janis, Jeffrey E. ;

Attinger, Christopher E. .

PLASTIC AND RECONSTRUCTIVE SURGERY, 2006, 117 (07) :12S-34S

[6] Alcohol debridement of the corneal epithelium in PRK and LASEK: An electron microscopic study [J].

Browning, AC ;

Shah, S ;

Dua, HS ;

Maharajan, SV ;

Gray, T ;

Bragheeth, MA .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 (02) :510-513

[7] Calcium phosphate nanoparticles in biomineralization and biomaterials [J].

Cai, Yurong ;

Tang, Ruikang .

JOURNAL OF MATERIALS CHEMISTRY, 2008, 18 (32) :3775-3787

[8] Nitric oxide release: Part II. Therapeutic applications [J].

Carpenter, Alexis W. ;

Schoenfisch, Mark H. .

CHEMICAL SOCIETY REVIEWS, 2012, 41 (10) :3742-3752

[9] Influence of Scaffold Size on Bactericidal Activity of Nitric Oxide-Releasing Silica Nanoparticles [J].

Carpenter, Alexis W. ;

Slomberg, Danielle L. ;

Rao, Kavitha S. ;

Schoenfisch, Mark H. .

ACS NANO, 2011, 5 (09) :7235-7244

[10] Competitive Formation of N-Diazeniumdiolates and N-Nitrosamines via Anaerobic Reactions of Polyamines with Nitric Oxide [J].

Coneski, Peter N. ;

Schoenfisch, Mark H. .

ORGANIC LETTERS, 2009, 11 (23) :5462-5465

← 1 2 3 4 5 6 7 →