RIP kinases as modulators of inflammation and immunity

被引：180
作者：
He, Sudan [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
Wang, Xiaodong [8 ,9 ,10 ]
机构：
[1] Chinese Acad Med Sci, Inst Basic Med Sci, Ctr Syst Med, Beijing, Peoples R China
[2] Peking Union Medial Coll, Beijing, Peoples R China
[3] Suzhou Inst Syst Med, Suzhou, Jiangsu, Peoples R China
[4] Soochow Univ, Cyrus Tang Hematol Ctr, Suzhou, Jiangsu, Peoples R China
[5] Soochow Univ, State Key Lab Radiat Med & Protect, Collaborat Innovat Ctr Hematol, Suzhou, Jiangsu, Peoples R China
[6] Soochow Univ, Key Lab Stem Cells & Biomed Mat Jiangsu Prov, Suzhou, Jiangsu, Peoples R China
[7] Soochow Univ, Chinese Minist Sci & Technol, Suzhou, Jiangsu, Peoples R China
[8] Natl Inst Biol Sci, Beijing, Peoples R China
[9] Zhongguancun Life Sci Pk, Beijing, Peoples R China
[10] Tsinghua Univ, Tsinghua Inst Multidisciplinary Biomed Res, Beijing, Peoples R China
来源：
NATURE IMMUNOLOGY | 2018年 / 19卷 / 09期
基金：
中国国家自然科学基金;
关键词：
RECEPTOR-INTERACTING PROTEIN; KAPPA-B ACTIVATION; TUMOR-NECROSIS-FACTOR; MIXED LINEAGE KINASE; DOMAIN-LIKE PROTEIN; NECROPTOTIC CELL-DEATH; PROGRAMMED NECROSIS; NLRP3; INFLAMMASOME; CANCER-CELLS; STAPHYLOCOCCUS-AUREUS;
D O I：
10.1038/s41590-018-0188-x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Receptor-interacting protein (RIP) kinases, in particular RIPK1, RIPK2 and RIPK3, have emerged as pleiotropic modulators of inflammatory responses that act either by directly regulating intracellular inflammatory signaling pathways or by causing apoptotic or necrotic cell death. In this Review, we discuss the signaling pathways and immunological functions of these RIP kinases in the inflammatory response to microbial infection and tissue injury, as well as their potential roles in the pathogenesis of inflammatory disease and aging.
引用
收藏
页码：912 / 922
页数：11
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