RIP kinases as modulators of inflammation and immunity

被引：180
作者：
He, Sudan [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
Wang, Xiaodong [8 ,9 ,10 ]
机构：
[1] Chinese Acad Med Sci, Inst Basic Med Sci, Ctr Syst Med, Beijing, Peoples R China
[2] Peking Union Medial Coll, Beijing, Peoples R China
[3] Suzhou Inst Syst Med, Suzhou, Jiangsu, Peoples R China
[4] Soochow Univ, Cyrus Tang Hematol Ctr, Suzhou, Jiangsu, Peoples R China
[5] Soochow Univ, State Key Lab Radiat Med & Protect, Collaborat Innovat Ctr Hematol, Suzhou, Jiangsu, Peoples R China
[6] Soochow Univ, Key Lab Stem Cells & Biomed Mat Jiangsu Prov, Suzhou, Jiangsu, Peoples R China
[7] Soochow Univ, Chinese Minist Sci & Technol, Suzhou, Jiangsu, Peoples R China
[8] Natl Inst Biol Sci, Beijing, Peoples R China
[9] Zhongguancun Life Sci Pk, Beijing, Peoples R China
[10] Tsinghua Univ, Tsinghua Inst Multidisciplinary Biomed Res, Beijing, Peoples R China
来源：
NATURE IMMUNOLOGY | 2018年 / 19卷 / 09期
基金：
中国国家自然科学基金;
关键词：
RECEPTOR-INTERACTING PROTEIN; KAPPA-B ACTIVATION; TUMOR-NECROSIS-FACTOR; MIXED LINEAGE KINASE; DOMAIN-LIKE PROTEIN; NECROPTOTIC CELL-DEATH; PROGRAMMED NECROSIS; NLRP3; INFLAMMASOME; CANCER-CELLS; STAPHYLOCOCCUS-AUREUS;
D O I：
10.1038/s41590-018-0188-x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Receptor-interacting protein (RIP) kinases, in particular RIPK1, RIPK2 and RIPK3, have emerged as pleiotropic modulators of inflammatory responses that act either by directly regulating intracellular inflammatory signaling pathways or by causing apoptotic or necrotic cell death. In this Review, we discuss the signaling pathways and immunological functions of these RIP kinases in the inflammatory response to microbial infection and tissue injury, as well as their potential roles in the pathogenesis of inflammatory disease and aging.
引用
收藏
页码：912 / 922
页数：11
相关论文
共 169 条
  • [1] Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity
    Aaes, Tania Love
    Kaczmarek, Agnieszka
    Delvaeye, Tinneke
    De Craene, Bram
    De Koker, Stefaan
    Heyndrickx, Liesbeth
    Delrue, Iris
    Taminau, Joachim
    Wiernicki, Bartosz
    De Groote, Philippe
    Garg, Abhishek D.
    Leybaert, Luc
    Grooten, Johan
    Bertrand, Mathieu J. M.
    Agostinis, Patrizia
    Berx, Geert
    Declercq, Wim
    Vandenabeele, Peter
    Krysko, Dmitri V.
    [J]. CELL REPORTS, 2016, 15 (02): : 274 - 287
  • [2] Death receptors: Signaling and modulation
    Ashkenazi, A
    Dixit, VM
    [J]. SCIENCE, 1998, 281 (5381) : 1305 - 1308
  • [3] XIAP regulates cytosol-specific innate immunity to Listeria infection
    Bauler, Laura D.
    Duckett, Colin S.
    O'Riordan, Mary X. D.
    [J]. PLOS PATHOGENS, 2008, 4 (08)
  • [4] Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice
    Berger, Scott B.
    Kasparcova, Viera
    Hoffman, Sandy
    Swift, Barb
    Dare, Lauren
    Schaeffer, Michelle
    Capriotti, Carol
    Cook, Michael
    Finger, Joshua
    Hughes-Earle, Angela
    Harris, Philip A.
    Kaiser, William J.
    Mocarski, Edward S.
    Bertin, John
    Gough, Peter J.
    [J]. JOURNAL OF IMMUNOLOGY, 2014, 192 (12) : 5476 - 5480
  • [5] NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling
    Biton, Sharon
    Ashkenazi, Avi
    [J]. CELL, 2011, 145 (01) : 92 - 103
  • [6] The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation
    Bonnet, Marion C.
    Preukschat, Daniela
    Welz, Patrick-Simon
    van Loo, Geert
    Ermolaeva, Maria A.
    Bloch, Wilhelm
    Haase, Ingo
    Pasparakis, Manolis
    [J]. IMMUNITY, 2011, 35 (04) : 572 - 582
  • [7] Necroptosis activation in Alzheimer's disease
    Caccamo, Antonella
    Branca, Caterina
    Piras, Ignazio S.
    Ferreira, Eric
    Huentelman, Matthew J.
    Liang, Winnie S.
    Readhead, Ben
    Dudley, Joel T.
    Spangenberg, Elizabeth E.
    Green, Kim N.
    Belfiore, Ramona
    Winslow, Wendy
    Oddo, Salvatore
    [J]. NATURE NEUROSCIENCE, 2017, 20 (09) : 1236 - +
  • [8] Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
    Cai, Zhenyu
    Jitkaew, Siriporn
    Zhao, Jie
    Chiang, Hsueh-Cheng
    Choksi, Swati
    Liu, Jie
    Ward, Yvona
    Wu, Ling-gang
    Liu, Zheng-Gang
    [J]. NATURE CELL BIOLOGY, 2014, 16 (01) : 55 - +
  • [9] NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease
    Caruso, Roberta
    Warner, Neil
    Inohara, Naohiro
    Nunez, Gabriel
    [J]. IMMUNITY, 2014, 41 (06) : 898 - 908
  • [10] A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses
    Chan, FKM
    Shisler, J
    Bixby, JG
    Felices, M
    Zheng, LX
    Appel, M
    Orenstein, J
    Moss, B
    Lenardo, MJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (51) : 51613 - 51621
12345678910