Magic touch: how does cell-cell adhesion trigger actin assembly?

被引：84
作者：
Bershadsky, A [1 ]
机构：
[1] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel
来源：
TRENDS IN CELL BIOLOGY | 2004年 / 14卷 / 11期
关键词：
D O I：
10.1016/j.tcb.2004.09.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The formation of cadherin-mediated cell-cell junctions is accompanied by a profound remodeling of the actin cytoskeleton. The Arp2/3 complex and its activator cortactin drive the assembly of branching actin-filament arrays, and formin-1 promotes the nucleation of non-branching actin filaments. Recruitment of these actin nucleators to nascent adhesions, formation of the links between them and the cytoplasmic cadherin domain, and triggering of their actin-polymerizing functions are vital steps in the development of cell-cell junctions. In this article, I discuss recent results showing that proteins involved in the regulation of actin polymerization have crucial roles in the development and maintenance of the cadherin junctions.
引用
收藏
页码：589 / 593
页数：5
相关论文
共 30 条
[1]   Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells [J].
Bougnères, L ;
Girardin, SE ;
Weed, SA ;
Karginov, AV ;
Olivo-Marin, JC ;
Parsons, JT ;
Sansonetti, PJ ;
Van Nhieu, GT .
JOURNAL OF CELL BIOLOGY, 2004, 166 (02) :225-235
[2]   Cortactin signalling and dynamic actin networks [J].
Daly, RJ .
BIOCHEMICAL JOURNAL, 2004, 382 :13-25
[3]   Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion [J].
DeMali, KA ;
Barlow, CA ;
Burridge, K .
JOURNAL OF CELL BIOLOGY, 2002, 159 (05) :881-891
[4]   Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck [J].
Eden, S ;
Rohatgi, R ;
Podtelejnikov, AV ;
Mann, M ;
Kirschner, MW .
NATURE, 2002, 418 (6899) :790-793
[5]   Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton [J].
Head, JA ;
Jiang, DY ;
Li, M ;
Zorn, LJ ;
Schaefer, EM ;
Parsons, JT ;
Weed, SA .
MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (08) :3216-3229
[6]   Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization [J].
Helwani, FM ;
Kovacs, EM ;
Paterson, AD ;
Verma, S ;
Ali, RG ;
Fanning, AS ;
Weed, SA ;
Yap, AS .
JOURNAL OF CELL BIOLOGY, 2004, 164 (06) :899-910
[7]   Actin polymerization-driven molecular movement of mDia1 in living cells [J].
Higashida, C ;
Miyoshi, T ;
Fujita, A ;
OcegueraYanez, F ;
Monypenny, J ;
Andou, Y ;
Narumiya, S ;
Watanabe, N .
SCIENCE, 2004, 303 (5666) :2007-2010
[8]   Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex [J].
Ho, HYH ;
Rohatgi, R ;
Lebensohn, AM ;
Ma, L ;
Li, JX ;
Gygi, SP ;
Kirschner, MW .
CELL, 2004, 118 (02) :203-216
[9]   α-catenin:: At the junction of intercellular adhesion and actin dynamics [J].
Kobielak, A ;
Fuchs, E .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (08) :614-625
[10]   Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables [J].
Kobielak, A ;
Pasolli, HA ;
Fuchs, E .
NATURE CELL BIOLOGY, 2004, 6 (01) :21-U2
123