Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesia

被引：30
作者：
Yoder, KK
Hutchins, GD
Morris, ED
Brashear, A
Wang, CZ
Shekhar, A
机构：
[1] Res Inst 2, Dept Radiol, Div Res, Sect Imgaing Sci, Indianapolis, IN 46202 USA
[2] Indiana Univ Purdue Univ, Purdue Sch Engn & Technol, Indianapolis, IN USA
[3] Indiana Univ, Sch Med, Dept Neurol, Indianapolis, IN 46204 USA
[4] Indiana Univ, Sch Med, Dept Psychiat & Pharmacol, Indianapolis, IN 46204 USA
[5] Indiana Univ, Sch Med, Dept Toxicol, Indianapolis, IN 46204 USA
来源：
SCHIZOPHRENIA RESEARCH | 2004年 / 71卷 / 2-3期
关键词：
schizophrenia; FANSS; dopamine transporter; caudate; putamen; tardive dyskinesia;
D O I：
10.1016/j.schres.2004.03.015
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Striatal dopamine transporter (DAT) binding potential (BP) was compared between schizophrenic subjects with and without tardive dyskinesia and controls. Although the groups were not statistically different in striatal BP, tardive subjects had apparently lower DAT density than non-tardive schizophrenic subjects. Significant and trend-level inverse correlations were found between DAT BP in the striatum, and especially the severity of negative symptom scores, but also cognitive, and depression/anxiety scores on the PANSS. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：371 / 375
页数：5
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