Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesia

被引：30
作者：
Yoder, KK
Hutchins, GD
Morris, ED
Brashear, A
Wang, CZ
Shekhar, A
机构：
[1] Res Inst 2, Dept Radiol, Div Res, Sect Imgaing Sci, Indianapolis, IN 46202 USA
[2] Indiana Univ Purdue Univ, Purdue Sch Engn & Technol, Indianapolis, IN USA
[3] Indiana Univ, Sch Med, Dept Neurol, Indianapolis, IN 46204 USA
[4] Indiana Univ, Sch Med, Dept Psychiat & Pharmacol, Indianapolis, IN 46204 USA
[5] Indiana Univ, Sch Med, Dept Toxicol, Indianapolis, IN 46204 USA
来源：
SCHIZOPHRENIA RESEARCH | 2004年 / 71卷 / 2-3期
关键词：
schizophrenia; FANSS; dopamine transporter; caudate; putamen; tardive dyskinesia;
D O I：
10.1016/j.schres.2004.03.015
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Striatal dopamine transporter (DAT) binding potential (BP) was compared between schizophrenic subjects with and without tardive dyskinesia and controls. Although the groups were not statistically different in striatal BP, tardive subjects had apparently lower DAT density than non-tardive schizophrenic subjects. Significant and trend-level inverse correlations were found between DAT BP in the striatum, and especially the severity of negative symptom scores, but also cognitive, and depression/anxiety scores on the PANSS. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：371 / 375
页数：5
相关论文
共 50 条
[31]   Polymorphisms of dopamine degradation enzyme (COMT and MAO) genes and tardive dyskinesia in patients with schizophrenia [J].
Matsumoto, C ;
Shinkai, T ;
Hori, H ;
Ohmori, O ;
Nakamura, J .
PSYCHIATRY RESEARCH, 2004, 127 (1-2) :1-7
[32]   Tardive dyskinesia and conversion disorder in a paranoid young schizophrenic patient with treated HIV [J].
Humbert, T .
ANNALES MEDICO-PSYCHOLOGIQUES, 2003, 161 (01) :74-77
[33]   Valbenazine and deutetrabenazine: Vesicular monoamine transporter 2 inhibitors for tardive dyskinesia [J].
Khorassani, Farah ;
Luther, Kiranjit ;
Talreja, Om .
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2020, 77 (03) :167-174
[34]   Atypical Antipsychotic-Induced Tardive Dyskinesia in a Middle-Aged Schizophrenic Patient: A Case Report [J].
Mulla, Walaa E. .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (07)
[35]   Association study of the vesicular monoamine transporter gene SLC18A2 with tardive dyskinesia [J].
Zai, Clement C. ;
Tiwari, Arun K. ;
Mazzoco, Marina ;
de Luca, Vincenzo ;
Mueller, Daniel J. ;
Shaikh, Sajid A. ;
Lohoff, Falk W. ;
Freeman, Natalie ;
Voineskos, Aristotle N. ;
Potkin, Steven G. ;
Lieberman, Jeffrey A. ;
Meltzer, Herbert Y. ;
Remington, Gary ;
Kennedy, James L. .
JOURNAL OF PSYCHIATRIC RESEARCH, 2013, 47 (11) :1760-1765
[36]   DOPAMINE RECEPTOR ABNORMALITIES IN THE STRIATUM AND PALLIDUM IN TARDIVE-DYSKINESIA - A POST-MORTEM STUDY [J].
REYNOLDS, GP ;
BROWN, JE ;
MCCALL, JC ;
MACKAY, AVP .
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION, 1992, 87 (03) :225-230
[37]   Association of TaqI a polymorphism of dopamine D-2 receptor gene and tardive dyskinesia in schizophrenia [J].
Chen, CH ;
Wei, FC ;
Koong, FJ ;
Hsiao, KJ .
BIOLOGICAL PSYCHIATRY, 1997, 41 (07) :827-829
[38]   Genotypic association between the dopamine D3 receptor and tardive dyskinesia in chronic schizophrenia [J].
R Segman ;
T Neeman ;
U Heresco-Levy ;
B Finkel ;
L Karagichev ;
M Schlafman ;
A Dorevitch ;
A Yakir ;
A Lerner ;
A Shelevoy ;
B Lerer .
Molecular Psychiatry, 1999, 4 :247-253
[39]   Genotypic association between the dopamine D3 receptor and tardive dyskinesia in chronic schizophrenia [J].
Segman, R ;
Neeman, T ;
Heresco-Levy, U ;
Finkel, B ;
Karagichev, L ;
Schlafman, M ;
Dorevitch, A ;
Yakir, A ;
Lerner, A ;
Shelevoy, A ;
Lerer, B .
MOLECULAR PSYCHIATRY, 1999, 4 (03) :247-253
[40]   Increased S100B serum levels in schizophrenic patients with tardive dyskinesia: Association with dyskinetic movements [J].
Zhang, Xiang Yang ;
Xiu, Mei Hong ;
Chen, Da Chun ;
Zhu, Feng Yan ;
Wu, Gui Ying ;
Haile, Colin N. ;
Lu, Lin ;
Kosten, Therese A. ;
Kosten, Thomas R. .
JOURNAL OF PSYCHIATRIC RESEARCH, 2010, 44 (07) :429-433
12345