Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesia

被引：30
作者：
Yoder, KK
Hutchins, GD
Morris, ED
Brashear, A
Wang, CZ
Shekhar, A
机构：
[1] Res Inst 2, Dept Radiol, Div Res, Sect Imgaing Sci, Indianapolis, IN 46202 USA
[2] Indiana Univ Purdue Univ, Purdue Sch Engn & Technol, Indianapolis, IN USA
[3] Indiana Univ, Sch Med, Dept Neurol, Indianapolis, IN 46204 USA
[4] Indiana Univ, Sch Med, Dept Psychiat & Pharmacol, Indianapolis, IN 46204 USA
[5] Indiana Univ, Sch Med, Dept Toxicol, Indianapolis, IN 46204 USA
来源：
SCHIZOPHRENIA RESEARCH | 2004年 / 71卷 / 2-3期
关键词：
schizophrenia; FANSS; dopamine transporter; caudate; putamen; tardive dyskinesia;
D O I：
10.1016/j.schres.2004.03.015
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Striatal dopamine transporter (DAT) binding potential (BP) was compared between schizophrenic subjects with and without tardive dyskinesia and controls. Although the groups were not statistically different in striatal BP, tardive subjects had apparently lower DAT density than non-tardive schizophrenic subjects. Significant and trend-level inverse correlations were found between DAT BP in the striatum, and especially the severity of negative symptom scores, but also cognitive, and depression/anxiety scores on the PANSS. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：371 / 375
页数：5
相关论文
共 50 条
[21]   Differential effect of haloperidol and clozapine on plasma homovanillic acid in elderly schizophrenic patients with or without tardive dyskinesia [J].
Andia, I ;
Zumarraga, M ;
Zabalo, MJ ;
Bulbena, A ;
Davila, R .
BIOLOGICAL PSYCHIATRY, 1998, 43 (01) :20-23
[22]   Polymorphisms of dopamine receptors and tardive dyskinesia among Chinese patients with schizophrenia [J].
Chong, SA ;
Tan, EC ;
Tan, CH ;
Mythily ;
Chan, YH .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2003, 116B (01) :51-54
[23]   Blood superoxide dismutase level in schizophrenic patients with tardive dyskinesia: association with dyskinetic movements [J].
Zhang, XY ;
Zhou, DF ;
Cao, LY ;
Chen, DC ;
Zhu, FY ;
Wu, GY .
SCHIZOPHRENIA RESEARCH, 2003, 62 (03) :245-250
[24]   Effects of nifedipine, a calcium channel antagonist, on cognitive function in schizophrenic patients with tardive dyskinesia [J].
Schwartz, BL ;
FayMcCarthy, M ;
Kendrick, K ;
Rosse, RB ;
Deutsch, SI .
CLINICAL NEUROPHARMACOLOGY, 1997, 20 (04) :364-370
[25]   Remission of severe tardive dyskinesia in a schizophrenic patient treated with the atypical antipsychotic substance quetiapine [J].
Vesely, C ;
Küfferle, B ;
Brücke, T ;
Kasper, S .
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 2000, 15 (01) :57-60
[26]   Neuroleptic drugs alter the dopamine transporter-mediated uptake and release of dopamine: A possible mechanism for drug-induced tardive dyskinesia [J].
Lee, SH ;
Oh, DY ;
Jung, SC ;
Kim, YM ;
Cho, HK ;
Koh, JK ;
Lee, YS .
PHARMACOLOGICAL RESEARCH, 1997, 35 (05) :447-450
[27]   COGNITIVE FUNCTIONS IN CHRONIC-SCHIZOPHRENIC PATIENTS WITH TARDIVE-DYSKINESIA [J].
SONI, SD ;
NEILL, D ;
SHEFFIELD, B .
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 1993, 8 (04) :233-242
[28]   Tardive dyskinesia in a chronically institutionalized population of elderly schizophrenic patients: Prevalence and association with cognitive impairment [J].
Byne, W ;
White, L ;
Parella, M ;
Adams, R ;
Harvey, PD ;
Davis, KL .
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 1998, 13 (07) :473-479
[29]   Decreased serum brain-derived neurotrophic factor levels in schizophrenic patients with tardive dyskinesia [J].
Yang, Yan Qiu ;
Sun, Shilong ;
Yu, Ya Qin ;
Li, Wen Jun ;
Zhang, Xuan ;
Xiu, Mei Hong ;
Chen, Da Chun ;
Yang, Fu De ;
Liu, Haibo ;
Li, Cunbo ;
Kosten, Thomas R. ;
Zhang, Xiang Yang .
NEUROSCIENCE LETTERS, 2011, 502 (01) :37-40
[30]   Dopamine transporter density may be associated with the depressed affect in healthy subjects [J].
Newberg, Andrew ;
Amsterdam, Jay ;
Shults, Justine .
NUCLEAR MEDICINE COMMUNICATIONS, 2007, 28 (01) :3-6
12345