Antigenic and virological properties of an H3N2 variant that continues to dominate the 2021-22 Northern Hemisphere influenza season

被引：26

作者：

Bolton, Marcus J. ^{[1
]}

Ort, Jordan T. ^{[1
]}

McBride, Ryan ^{[2
,3
]}

Swanson, Nicholas J. ^{[4
]}

Wilson, Jo ^{[4
]}

Awofolaju, Moses ^{[1
]}

Furey, Colleen ^{[1
]}

Greenplate, Allison R. ^{[5
]}

Drapeau, Elizabeth M. ^{[1
]}

Pekosz, Andrew ^{[4
]}

Paulson, James C. ^{[2
,3
]}

Hensley, Scott E. ^{[1
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA

[2] Scripps Res Inst, Dept Mol Med, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA

[4] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

[5] Univ Penn, Inst Immunol & Immune Hlth, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

CELL REPORTS | 2022年 / 39卷 / 09期

基金：

美国国家卫生研究院;

关键词：

ANTIBODIES; BINDING; VIRUSES; SITE;

D O I：

10.1016/j.celrep.2022.110897

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Influenza viruses circulated at very low levels during the beginning of the COVID-19 pandemic, and population immunity against these viruses is low. An H3N2 strain (3C.2a1b.2a2) with a hemagglutinin (HA) that has several substitutions relative to the 2021???22 H3N2 vaccine strain is dominating the 2021???22 Northern Hemisphere influenza season. Here, we show that one of these substitutions eliminates a key glycosylation site on HA and alters sialic acid binding. Using glycan array profiling, we show that the 3C.2a1b.2a2 H3 maintains binding to an extended biantennary sialoside and replicates to high titers in human airway cells. We find that antibodies elicited by the 2021???22 Northern Hemisphere influenza vaccine poorly neutralize the 3C.2a1b.2a2 H3N2 strain. Together, these data indicate that 3C.2a1b.2a2 H3N2 viruses efficiently replicate in human cells and escape vaccine-elicited antibodies.

引用

页数：10

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