The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1

被引：231

作者：

Li, LH

Milner, LA

Deng, Y

Iwata, M

Banta, A

Graf, L

Marcovina, S

Friedman, C

Trask, BJ

Hood, L ^{[1
]}

Torok-Storb, B

机构：

[1] Univ Washington, Stower Inst Med Res, Seattle, WA 98195 USA

[2] Univ Washington, Dept Mol Biotechnol, Seattle, WA 98195 USA

[3] Univ Washington, NW Lipid Res Lab, Seattle, WA 98195 USA

[4] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA

[5] Fudan Univ, Inst Genet, Shanghai 200433, Peoples R China

来源：

IMMUNITY | 1998年 / 8卷 / 01期

关键词：

D O I：

10.1016/S1074-7613(00)80457-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A cDNA clone encoding the human homolog of rat Jagged1 was isolated from normal human marrow. Analyses of human stromal cell lines indicate that this gene, designated hJagged1, is expressed by marrow stromal cells typified by the cell line HS-27a, which supports the long-term maintenance of hematopoietic progenitor cells. G-CSF-induced differentiation of 32D cells expressing Notch1 was inhibited by coculturing with HS-27a. A peptide corresponding to the Delta/Serrate/LAG-2 domain of hJagged1 and supernatants from COS cells expressing a soluble form of the extracellular portion of hJagged1 were able to mimic this effect. These observations suggest that hJagged1 may function as a ligand for Notch1 and play a role in mediating cell fate decisions during hematopoiesis.

引用

页码：43 / 55

页数：13

共 62 条

[31] MARCOVINA S, 1990, J LIPID RES, V31, P375
[32] THE MATERNAL GENES APX-1 AND GLP-1 AND ESTABLISHMENT OF DORSAL-VENTRAL POLARITY IN THE EARLY C-ELEGANS EMBRYO
MELLO, CC
DRAPER, BW
PRIESS, JR
[J]. CELL, 1994, 77 (01) : 95 - 106
[33] Inhibition of granulocytic differentiation by mNotch1
Milner, LA
Bigas, A
Kopan, R
BrashemStein, C
Bernstein, ID
Martin, DIK
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (23) : 13014 - 13019
[34] Mitsiadis TA, 1997, DEVELOPMENT, V124, P1473
[35] EXPRESSION OF NOTCH-1, NOTCH-2, AND NOTCH-3 IS REGULATED BY EPITHELIAL-MESENCHYMAL INTERACTIONS AND RETINOIC ACID IN THE DEVELOPING MOUSE TOOTH AND ASSOCIATED WITH DETERMINATION OF AMELOBLAST CELL FATE
MITSIADIS, TA
LARDELLI, M
LENDAHL, U
THESLEFF, I
[J]. JOURNAL OF CELL BIOLOGY, 1995, 130 (02) : 407 - 418
[36] MLLNER LA, 1994, BLOOD, V83, P2057
[37] Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs
Moore, KA
Pytowski, B
Witte, L
Hicklin, D
Lemischka, IR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) : 4011 - 4016
[38] Muskavitch M.A.T., 1990, Current Topics in Developmental Biology, V24, P289, DOI 10.1016/S0070-2153(08)60091-5
[39] A chick homologue of Serrate and its relationship with Notch and Delta homologues during central neurogenesis
Myat, A
Henrique, D
IshHorowicz, D
Lewis, J
[J]. DEVELOPMENTAL BIOLOGY, 1996, 174 (02) : 233 - 247
[40] DEVELOPMENTAL SIGNALING - VERTEBRATE LIGANDS FOR NOTCH
NYE, JS
KOPAN, R
[J]. CURRENT BIOLOGY, 1995, 5 (09) : 966 - 969

← 1 2 3 4 5 6 7 →