Direct carbodiimide-mediated conjugation of carboxylates using pyridinium p-toluenesulfonate and tertiary amines as additives

被引：15

作者：

Ficht, S ^{[1
]}

Röglin, L ^{[1
]}

Ziehe, M ^{[1
]}

Breyer, D ^{[1
]}

Seitz, O ^{[1
]}

机构：

[1] Humboldt Univ, Inst Chem, D-12489 Berlin, Germany

来源：

SYNLETT | 2004年 / 14期

关键词：

amides; coupling; carbodiimides; carboxylates; solid-phase synthesis;

D O I：

10.1055/s-2004-834819

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of carboxylates in the carbodiimide-mediated coupling to amines was investigated. The addition of pyridinium p-toluenesulfonate (PPTS) and a tertiary amine was found to significantly improve acylation yields by up to 70%.

引用

页码：2525 / 2528

页数：4

共 3 条

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