Mutations in the highly conserved RecQ helicase, BLM, cause the rare cancer predisposition disorder, Bloom's syndrome. The orthologues of BLM in Saccharomyces cerevisiae and Schizosaccharomyces pombe are SGS1 and rqh1(+), respectively. Studies in these yeast species have revealed a plethora of roles for the Sgs1 and Rqhl proteins in repair of double strand breaks, restart of stalled replication forks, processing of aberrant intermediates that arise during meiotic recombination, and maintenance of telomeres. In this review, we focus on the known roles of Sgs1 and Rqh1 and how studies in yeast species have improved our knowledge of how BLM suppresses neoplastic transformation. C 2009 Elsevier B.V. All rights reserved.
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Sungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Natl Creat Res Initiat Ctr Cell Cycle Control, Suwon 440746, South KoreaSungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Natl Creat Res Initiat Ctr Cell Cycle Control, Suwon 440746, South Korea
Bae, SH
Bae, KH
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Sungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Natl Creat Res Initiat Ctr Cell Cycle Control, Suwon 440746, South KoreaSungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Natl Creat Res Initiat Ctr Cell Cycle Control, Suwon 440746, South Korea
Bae, KH
Kim, JA
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Sungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Natl Creat Res Initiat Ctr Cell Cycle Control, Suwon 440746, South KoreaSungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Natl Creat Res Initiat Ctr Cell Cycle Control, Suwon 440746, South Korea
Kim, JA
Seo, YS
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Sungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Natl Creat Res Initiat Ctr Cell Cycle Control, Suwon 440746, South KoreaSungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Natl Creat Res Initiat Ctr Cell Cycle Control, Suwon 440746, South Korea
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Sungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Natl Creat Res Initiat Ctr Cell Cycle Control, Suwon 440746, South KoreaSungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Natl Creat Res Initiat Ctr Cell Cycle Control, Suwon 440746, South Korea
Bae, SH
Bae, KH
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Sungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Natl Creat Res Initiat Ctr Cell Cycle Control, Suwon 440746, South KoreaSungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Natl Creat Res Initiat Ctr Cell Cycle Control, Suwon 440746, South Korea
Bae, KH
Kim, JA
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Sungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Natl Creat Res Initiat Ctr Cell Cycle Control, Suwon 440746, South KoreaSungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Natl Creat Res Initiat Ctr Cell Cycle Control, Suwon 440746, South Korea
Kim, JA
Seo, YS
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Sungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Natl Creat Res Initiat Ctr Cell Cycle Control, Suwon 440746, South KoreaSungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Natl Creat Res Initiat Ctr Cell Cycle Control, Suwon 440746, South Korea